Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Identification of a putative azadirachtin-binding complex from Drosophila Kc167 cells
Archives of insect biochemistry and physiology
(2007)
64
200
(doi: 10.1002/arch.20171)
Fully Automated Flow-Through Synthesis of Secondary Sulfonamides in a Binary Reactor System
J Comb Chem
(2007)
9
422
(doi: 10.1021/cc060152b)
Total synthesis of rapamycin
Angewandte Chemie International Edition
(2007)
46
591
(doi: 10.1002/anie.200604053)
Total synthesis of thapsigargin, a potent SERCA pump inhibitor
Org Lett
(2007)
9
663
(doi: 10.1021/ol062947x)
New avenues to efficient chemical synthesis
(2007)
151
Stent Imaging by means of 64-detector CT and 3-tesla-high field MRT in comparison with catheter angiography
CLINICAL RESEARCH IN CARDIOLOGY
(2007)
96
671
Elastance of the morphologically unobtrusive aorta in teenagers with Marfan's syndrome:: Detection of early changes by means of MRT
CLINICAL RESEARCH IN CARDIOLOGY
(2007)
96
695
Natural Products as an Inspiration for the Discovery of New High Throughput Chemical Synthesis Tools In Drug Discovery & Development
(2007)
51
A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Chemical Communications
(2006)
4835
(doi: 10.1039/b612197g)
A new asymmetric organocatalytic nitrocyclopropanation reaction.
Chemical communications (Cambridge, England)
(2006)
4838
(doi: 10.1039/b612436b)
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