Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas - Liquid contact
– Organic letters
(2010)
12,
1596
(doi: 10.1021/ol100322t)
A flow-based synthesis of Imatinib: The API of Gleevec
– Chem Commun (Camb)
(2010)
46,
2450
(doi: 10.1039/c001550d)
The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors
– Organic & Biomolecular Chemistry
(2010)
8,
1588
(doi: 10.1039/b924309g)
A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT1B Antagonist
– Synlett
(2010)
2010,
505
(doi: 10.1055/s-0029-1219358)
ReactIR flow cell: A new analytical tool for continuous flow chemical processing
– Organic Process Research and Development
(2010)
14,
393
(doi: 10.1021/op900305v)
Synthesis of 3-Nitropyrrolidines via Dipolar Cycloaddition Reactions Using a Modular Flow Reactor
– Synlett
(2010)
2010,
749
(doi: 10.1055/s-0029-1219344)
Multi-Step Synthesis by Using Modular Flow Reactors: The Preparation of Yne-Ones and Their Use in Heterocycle Synthesis
– Chemistry A European Journal
(2009)
16,
89
(doi: 10.1002/chem.200902906)
An Asymmetric Tandem Conjugative Addition-Intramolecular Cyclisation Process to Provide Functionalised 3,6-Dihydropyrans and 4,5-Epoxytetrahydropyrans
– European Journal of Organic Chemistry
(2009)
2010,
183
(doi: 10.1002/ejoc.200901145)
Total Synthesis of the Anti-Apoptotic Agents Iso- and Bongkrekic Acids
– Organic Letters
(2009)
12,
340
(doi: 10.1021/ol902676t)
Synthesis of Azadirachtin: A long but successful journey
– Chemtracts
(2009)
22,
214
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