Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Total syntheses of subereamollines A and B.
– Org. Biomol. Chem.
(2010)
9,
62
(doi: 10.1039/c0ob00636j)
Preparation of arylsulfonyl chlorides by chlorosulfonylation of in situ generated diazonium salts using a continuous flow reactor.
– Organic & biomolecular chemistry
(2010)
8,
5324
(doi: 10.1039/c0ob00450b)
A Continuous Flow Process Using a Sequence of Microreactors with In-line IR Analysis for the Preparation of N,N-Diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide as a Potent and Highly Selective δ-Opioid Receptor Agonist
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2010)
16,
12342
(doi: 10.1002/chem.201002147)
Total syntheses of the bromotyrosine-derived natural products ianthelline, 5-bromoverongamine and JBIR-44
– Tetrahedron Letters
(2010)
51,
4812
(doi: 10.1016/j.tetlet.2010.07.016)
DISPIROKETALS IN SYNTHESIS .16. FUNCTIONALIZED DISPIROKETALS AS NEW CHIRAL AUXILIARIES - THE SYNTHESIS OF DIHYDROXYLATED DISPIROKETALS IN OPTICALLY PURE FORM AND THEIR APPLICATION AS BIFUNCTIONAL, C-2-SYMMETRICAL, CHIRAL AUXILIARIES FOR HIGHLY STEREOSELECTIVE MICHAEL ADDITIONS
– Recueil des Travaux Chimiques des Pays-Bas
(2010)
114,
184
(doi: 10.1002/recl.19951140410)
Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4
– MedChemComm
(2010)
1,
202
(doi: 10.1039/c0md00095g)
New Routes to Biologically Active Heterocyclic Natural Products
– Bulletin Des Societes Chimiques Belges
(2010)
101,
641
(doi: 10.1002/bscb.19921010711)
Towards the total synthesis of leustroducsin B
– ABSTR PAP AM CHEM S
(2010)
240,
Flow chemistry for natural product synthesis: Towards the syntheses of spiragiens A and B
– ABSTR PAP AM CHEM S
(2010)
240,
Award Address (Tetrahedron Prize for Creativity in Organic Chemistry, sponsored by Elsevier). Changing face of organic synthesis
– ABSTR PAP AM CHEM S
(2010)
240,
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