Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

New Synthetic Technologies in Medicinal Chemistry Foreword

SV Ley

(2011)

11,

(doi: 10.1039/9781849733052-FP005)

The Lab of the Future The importance of remote monitoring and control

MD Hopkin, IR Baxendale, SV Ley

– Chimica Oggi

(2011)

29,

(link to publication)

The Continuous-Flow Synthesis of Carboxylic Acids using CO(2) in a Tube-In-Tube Gas Permeable Membrane Reactor.

A Polyzos, M O'Brien, TP Petersen, IR Baxendale, SV Ley

– Angewandte Chemie International Edition

(2010)

50,

1190

(doi: 10.1002/anie.201006618)

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

A Polyzos, M O'Brien, TP Petersen, IR Baxendale, SV Ley

– Angewandte Chemie

(2010)

123,

1222

(doi: 10.1002/ange.201006618)

Safe and reliable synthesis of diazoketones and quinoxalines in a continuous flow reactor.

LJ Martin, AL Marzinzik, SV Ley, IR Baxendale

– Org Lett

(2010)

13,

320

(doi: 10.1021/ol1027927)

Total Synthesis of Iso‐ and Bongkrekic Acids: Natural Antibiotics Displaying Potent Antiapoptotic Properties

A Français, A Leyva-Pérez, G Etxebarria-Jardi, J Peña, SV Ley

– Chemistry - A European Journal

(2010)

17,

329

(doi: 10.1002/chem.201002380)

Total synthesis of iso- and bongkrekic acids: natural antibiotics displaying potent antiapoptotic properties.

A Français, A Leyva-Pérez, G Etxebarria-Jardi, J Peña, SV Ley

– Chemistry (Weinheim an der Bergstrasse, Germany)

(2010)

17,

329

(doi: 10.1002/chem.201002380)

Trapping of palindromic ligands within native transthyretin prevents amyloid formation

SE Kolstoe, PP Mangione, V Bellotti, GW Taylor, GA Tennent, S Deroo, AJ Morrison, AJA Cobb, A Coyne, MG McCammon, TD Warner, J Mitchell, R Gill, MD Smith, SV Ley, CV Robinson, SP Wood, MB Pepys

– Proceedings of the National Academy of Sciences of the United States of America

(2010)

107,

20483

(doi: 10.1073/pnas.1008255107)