Professor Steve Ley CBE FRS FMedSci | Page 28 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Continuous flow processing of slurries: Evaluation of an agitated cell reactor

DL Browne, BJ Deadman, R Ashe, IR Baxendale, SV Ley

– Organic Process Research and Development

(2011)

15,

693

(doi: 10.1021/op2000223)

SYNTHESIS OF HIGHLY SUBSTITUTED NITROPYRROLIDINES, NITROPYRROLIZINES AND NITROPYRROLES VIA MULTICOMPONENT-MULTISTEP SEQUENCES WITHIN A FLOW REACTOR

M Baumann, IR Baxendale, A Kirschning, SV Ley, J Wegner

– Heterocycles

(2011)

82,

1297

(doi: 10.3987/com-10-s(e)77)

Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly

CF Carter, H Lange, D Sakai, IR Baxendale, SV Ley

– Chemistry – A European Journal

(2011)

17,

3398

(doi: 10.1002/chem.201003148)

Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid-binding Globulins*

X Qi, F Loiseau, WL Chan, Y Yan, Z Wei, L-G Milroy, RM Myers, SV Ley, RJ Read, RW Carrell, A Zhou

– J Biol Chem

(2011)

286,

16163

(doi: 10.1074/jbc.m110.171082)

The Continuous‐Flow Synthesis of Carboxylic Acids using CO2 in a Tube‐In‐Tube Gas Permeable Membrane Reactor

A Polyzos, M O'Brien, TP Petersen, IR Baxendale, SV Ley

– Angewandte Chemie International Edition

(2011)

50,

1190

(doi: 10.1002/anie.201006618)

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent.

CJ Smith, CD Smith, N Nikbin, SV Ley, IR Baxendale

– Organic & biomolecular chemistry

(2011)

9,

1927

(doi: 10.1039/c0ob00813c)

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3- triazoles

CJ Smith, N Nikbin, SV Ley, H Lange, IR Baxendale

– Org Biomol Chem

(2011)

9,

1938

(doi: 10.1039/c0ob00815j)

An integrated flow and batch-based approach for the synthesis of O -methyl siphonazole

M Baumann, IR Baxendale, M Brasholz, JJ Hayward, SV Ley, N Nikbin

– Synlett

(2011)

1375

(doi: 10.1055/s-0030-1260573)

Foreword

– Drug Discovery

(2011)

p005

(doi: 10.1039/9781849733052-fp005)

New Synthetic Technologies in Medicinal Chemistry Foreword

SV Ley

(2011)

11,

V

(doi: 10.1039/9781849733052-FP005)