Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Total Synthesis of Chloptosin: A Dimeric Cyclohexapeptide

AJ Oelke, F Antonietti, L Bertone, PB Cranwell, DJ France, RJM Goss, T Hofmann, S Knauer, SJ Moss, PC Skelton, RM Turner, G Wuitschik, SV Ley

Chemistry (Weinheim an der Bergstrasse, Germany)

(2011)

17

4183

(doi: 10.1002/chem.201003216)

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

DL Browne, BJ Deadman, R Ashe, IR Baxendale, SV Ley

Organic Process Research & Development

(2011)

15

693

(doi: 10.1021/op2000223)

Diastereoselective chain-elongation reactions using microreactors for applications in complex molecule assembly

CF Carter, H Lange, D Sakai, IR Baxendale, SV Ley

Chemistry

(2011)

17

3398

(doi: 10.1002/chem.201003148)

Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.

X Qi, F Loiseau, WL Chan, Y Yan, Z Wei, L-G Milroy, RM Myers, SV Ley, RJ Read, RW Carrell, A Zhou

Journal of Biological Chemistry

(2011)

286

16163

(doi: 10.1074/jbc.M110.171082)

The Continuous‐Flow Synthesis of Carboxylic Acids using CO₂ in a Tube‐In‐Tube Gas Permeable Membrane Reactor

A Polyzos, M O'Brien, TP Petersen, IR Baxendale, SV Ley

Angewandte Chemie (International ed. in English)

(2011)

50

1190

(doi: 10.1002/anie.201006618)

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

CJ Smith, CD Smith, N Nikbin, SV Ley, IR Baxendale

Organic & Biomolecular Chemistry

(2011)

9

1927

(doi: 10.1039/c0ob00813c)

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3- triazoles

CJ Smith, N Nikbin, SV Ley, H Lange, IR Baxendale

Org Biomol Chem

(2011)

9

1938

(doi: 10.1039/c0ob00815j)

New Synthetic Technologies in Medicinal Chemistry Foreword

SV Ley

(2011)

11

V

(doi: 10.1039/9781849733052-FP005)

An integrated flow and batch-based approach for the synthesis of O -methyl siphonazole

M Baumann, IR Baxendale, M Brasholz, JJ Hayward, SV Ley, N Nikbin

Synlett

(2011)

1375

(doi: 10.1055/s-0030-1260573)

Foreword

E Farrant

Drug Discovery

(2011)

P005

(doi: 10.1039/9781849733052-fp005)