Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Synthesis of (–)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods
– Synlett
(2013)
24,
514
(doi: 10.1055/s-0032-1318109)
A prototype device for evaporation in batch and flow chemical processes
– Green Chemistry
(2013)
15,
2050
(doi: 10.1039/c3gc40967h)
Flow chemistry synthesis of zolpidem, alpidem and other GABA A agonists and their biological evaluation through the use of in-line frontal affinity chromatography
– Chemical Science
(2013)
4,
764
(doi: 10.1039/c2sc21850j)
A Continuous Flow Solution to Achieving Efficient Aerobic Anti-Markovnikov Wacker Oxidation
– Advanced Synthesis and Catalysis
(2013)
342,
Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes
– ChemCatChem
(2012)
5,
159
(doi: 10.1002/cctc.201200778)
An expeditious synthesis of imatinib and analogues utilising flow chemistry methods.
– Organic and Biomolecular Chemistry
(2012)
11,
1822
(doi: 10.1039/c2ob27002a)
The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib
– Organic and Biomolecular Chemistry
(2012)
11,
1766
(doi: 10.1039/c2ob27003j)
Synthesis and use of a trifluoromethylated azomethine ylide precursor.
– The Journal of Organic Chemistry
(2012)
77,
11071
(doi: 10.1021/jo302052m)
Flow Microwave Technology and Microreactors in Synthesis
– Australian Journal of Chemistry
(2012)
66,
131
(doi: 10.1071/CH12365)
Synthesis of Enantiomerically Enriched 3-Amino-2-oxindoles through a Palladium-Mediated Asymmetric Intramolecular Arylation of α-Ketimino Amides
– Org Lett
(2012)
14,
4810
(doi: 10.1021/ol302119j)
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