Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
– Med. Chem. Commun.
(2014)
5,
540
(doi: 10.1039/c4md00007b)
Highly regioselective lithiation of pyridines bearing an oxetane unit by n -butyllithium
– Chem. Commun.
(2014)
50,
8908
(doi: 10.1039/c4cc03766a)
Investigation of a Lithium-Halogen Exchange Flow Process for the Preparation of Boronates by Using a Cryo-Flow Reactor
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2013)
20,
263
(doi: 10.1002/chem.201303736)
Metal-free coupling of saturated heterocyclic sulfonylhydrazones with boronic acids.
– The Journal of Organic Chemistry
(2013)
79,
328
(doi: 10.1021/jo402526z)
Fragment-based hit identification: Thinking in 3D
– Drug Discovery Today
(2013)
18,
1221
(doi: 10.1016/j.drudis.2013.07.011)
Abstract B96: Design, synthesis and biological evaluation of a novel allosteric inhibitor of HSET that damages cancer cells with supernumerary centrosomes.
– Molecular Cancer Therapeutics
(2013)
12,
B96
An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles.
– Beilstein Journal of Organic Chemistry
(2013)
9,
2265
(doi: 10.3762/bjoc.9.265)
Sustainable Flow Oppenauer Oxidation of Secondary Benzylic Alcohols with a Heterogeneous Zirconia Catalyst
– Organic Letters
(2013)
15,
5698
(doi: 10.1021/ol4027107)
Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes
– Chemistry and Biology
(2013)
20,
1399
Flow‐Based, Cerium Oxide Enhanced, Low‐Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts
– Israel Journal of Chemistry
(2013)
54,
371
(doi: 10.1002/ijch.201300049)
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