Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Accelerating spirocyclic polyketide synthesis using flow chemistry

S Newton, CF Carter, CM Pearson, L De C. Alves, H Lange, P Thansandote, SV Ley

Angewandte Chemie International Edition

(2014)

4915

(doi: 10.1002/anie.201402056)

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns.

J Hartwig, JB Metternich, N Nikbin, A Kirschning, SV Ley

Org Biomol Chem

(2014)

3611

(doi: 10.1039/c4ob00662c)

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

RJ Ingham, C Battilocchio, JM Hawkins, SV Ley

Beilstein J Org Chem

(2014)

641

(doi: 10.3762/bjoc.10.56)

Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide

C Battilocchio, JM Hawkins, SV Ley

Organic letters

(2014)

1060

(doi: 10.1021/ol403591c)

Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor

JA Newby, L Huck, DW Blaylock, PM Witt, SV Ley, DL Browne

Chemistry A European Journal

(2014)

263

(doi: 10.1002/chem.201303736)

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

L Guetzoyan, RJ Ingham, N Nikbin, J Rossignol, M Wolling, M Baumert, NA Burgess-Brown, CM Strain-Damerell, L Shrestha, PE Brennan, O Fedorov, S Knapp, SV Ley

Med. Chem. Commun.

(2014)

540

(doi: 10.1039/c4md00007b)

Highly regioselective lithiation of pyridines bearing an oxetane unit by n -butyllithium

G Rouquet, DC Blakemore, SV Ley

Chemical communications (Cambridge, England)

(2014)

8908

(doi: 10.1039/c4cc03766a)

Fully Automated Sequence-Specific Synthesis of α-Peptides Using Flow Chemistry

KR Knudsen, M Ladlow, Z Bandpey, SV Ley

Journal of Flow Chemistry

(2014)

(doi: 10.1556/jfc-d-13-00033)

Oppenauer oxidation using hydrous zirconia catalysts and cerium oxide enhanced Sonogashira reactions in flow by low-level palladium perovskite catalysts

RS Chorghade, C Battilocchio, SV Ley

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2014)

247

Metal-Free Coupling of Saturated Heterocyclic Sulfonylhydrazones with Boronic Acids

DM Allwood, DC Blakemore, AD Brown, SV Ley

The Journal of organic chemistry

(2013)

328

(doi: 10.1021/jo402526z)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

Publications

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