Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Dynamic flow synthesis of porous organic cages.
Chem Commun (Camb)
(2015)
51
17390
(doi: 10.1039/c5cc07447a)
An Orthogonal Biocatalytic Approach for the Safe Generation and Use of HCN in a Multistep Continuous Preparation of Chiral O-Acetylcyanohydrins
Synlett
(2015)
27
262
(doi: 10.1055/s-0035-1560644)
Sequence-based Process Modeling of Fluidized Bed Biomass Gasification
ACS Sustainable Chemistry & Engineering
(2015)
3
1453
A Short Multistep Flow Synthesis of a Potential Spirocyclic Fragrance Component
Chemical Engineering & Technology
(2015)
38
1713
(doi: 10.1002/ceat.201500255)
The Use of Gases in Flow Synthesis
Organic Process Research and Development
(2015)
20
327
(doi: 10.1021/acs.oprd.5b00222)
Callipeltosides A, B and C: Total Syntheses and Structural Confirmation.
Chemistry (Weinheim an der Bergstrasse, Germany)
(2015)
21
13261
(doi: 10.1002/chem.201501877)
The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry.
Beilstein J Org Chem
(2015)
11
1194
(doi: 10.3762/bjoc.11.134)
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.
European Journal of Medicinal Chemistry
(2015)
103
573
(doi: 10.1016/j.ejmech.2015.07.011)
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