Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a
D Diez-Martin, P Grice, HC Kolb, SV Ley, A Madin
Tetrahedron Letters
(1990)
31
(doi: 10.1016/s0040-4039(00)97418-5)
Chemistry of insect antifeedants from azadirachta indica (part 7): Preparation of an optically pure hydroxyacetal epoxide related to azadirachtin.
JC Anderson, SV Ley
Tetrahedron Letters
(1990)
31
(doi: 10.1016/S0040-4039(00)97416-1)
TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols
WP Griffith, SV Ley
Aldrichimica Acta
(1990)
23
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .6. SYNTHESIS OF AN OPTICALLY PURE ACETAL INTERMEDIATE FOR POTENTIAL USE IN THE SYNTHESIS OF AZADIRACHTIN AND NOVEL ANTIFEEDANTS
JC Anderson, SV Ley
Tetrahedron Letters
(1990)
31
(doi: 10.1016/s0040-4039(00)94574-x)
ASSESSMENT OF BUTENE-1,4-DIOLS AS STARTING MATERIALS FOR THE PREPARATION OF PI-ALLYLTRICARBONYLIRON COMPLEXES
RW Bates, D Díez-Martín, WJ Kerr, JG Knight, SV Ley, A Sakellaridis
Tetrahedron
(1990)
46
(doi: 10.1016/s0040-4020(01)90541-1)
The antifeedant activity of clerodane diterpenoids from Teucrium
MSJ Simmonds, WM Blaney, SV Ley, G Savona, M Bruno, B Rodriguez
Phytochemistry
(1989)
28
(doi: 10.1016/0031-9422(89)80184-0)
THE 1ST CRYSTAL AND MOLECULAR-STRUCTURE OF LANTHANIDE HOMODINUCLEAR MACROCYCLIC COMPLEXES SHOWING METAL METAL PAIR INTERACTIONS
IA Kahwa, S Folkes, DJ Williams, SV Ley, CA O'Mahoney, GL McPherson
Journal of the Chemical Society Chemical Communications
(1989)
(doi: 10.1039/c39890001531)
Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles
DS Brown, M Bruno, RJ Davenport, SV Ley
Tetrahedron
(1989)
45
(doi: 10.1016/S0040-4020(01)81323-5)
Insect antifeedants from azadirachta indica (part 5): Chemical modification and structure-activity relationships of azadirachtin and some related limonoids
SV Ley, JC Anderson, WM Blaney, PS Jones, Z Lidert, ED Morgan, NG Robinson, D Santafianos, MSJ Simmonds, PL Toogood
Tetrahedron
(1989)
45
(doi: 10.1016/s0040-4020(01)81095-4)
Microbial Oxidation in Synthesis: Preparation of (+)- and (-)-Pinitol from Benzene
SV Ley, F Sternfeld
Tetrahedron
(1989)
45
(doi: 10.1016/S0040-4020(01)81025-5)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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