Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A SIMPLE, ONE-POT, GLYCOSIDATION PROCEDURE VIA (1-IMIDAZOLYLCARBONYL) GLYCOSIDES AND ZINC BROMIDE
Synlett
(1990)
1990
255
(doi: 10.1055/s-1990-21053)
Alkenylcyclic Sulphites as Novel Precursors for the Preparation of π-Allyltricarbonyliron Lactone Complexes
Synlett
(1990)
1990
224
(doi: 10.1055/s-1990-21044)
Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene
Tetrahedron
(1990)
46
4995
Neo-clerodane insect antifeedants from Scutellaria galericulata
Phytochemistry
(1990)
29
1793
(doi: 10.1016/0031-9422(90)85018-B)
SYNTHESIS AND MODIFICATION OF AZADIRACHTIN AND RELATED ANTIFEEDANTS
RECENT ADVANCES IN THE CHEMISTRY OF INSECT CONTROL II
(1990)
79
90
SYNTHESIS OF ANTIFEEDANTS FOR INSECTS - NOVEL BEHAVIOR-MODIFYING CHEMICALS FROM PLANTS
CIBA FOUNDATION SYMPOSIA
(1990)
154
80
INSECT ANTIFEEDANTS
CHEM BRIT
(1990)
26
31
Direct Substitution of 2-Benzenesulphonylpiperidines and -pyrrolidines by Carbon Nucleophiles: Synthesis of the Pyrrolidine Alkaloid Ruspolinone
Synlett
(1990)
1990
48
(doi: 10.1055/s-1990-20983)
SYNTHESIS OF THE C12-C26 FRAGMENT OF THE ACYLTETRONIC ACID IONOPHORE ANTIBIOTIC TETRONASIN (ICI-139603)
Tetrahedron Letters
(1990)
31
5525
Enantioselective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603).
Tetrahedron Letters
(1990)
31
5521
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