Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .17. SYNTHESIS OF MODEL COMPOUNDS OF AZADIRACHTIN - UNUSUAL EFFECT OF REMOTE SUBSTITUENTS ON THE COURSE OF THE OXIDATIVE RING CONTRACTION REACTION

RB Grossman, SV Ley

Tetrahedron

(1994)

50

11553

(doi: 10.1016/S0040-4020(01)89292-9)

Chemistry of insect antifeedants from Azadirachta indica (Part 16): Synthesis of several derivatives of azadirachtin containing fluorescent or immunogenic reporter groups

RB Grossman, SV Ley

Tetrahedron

(1994)

50

8871

(doi: 10.1016/S0040-4020(01)85360-6)

The chemistry of azadirachtin

SV Ley, AA Denholm, A Wood

Natural Product Reports

(1993)

10

109

(doi: 10.1039/np9931000109)

Selective acylation and alkylation reactions of diols using dibutyltin dimethoxide

G-J Boons*, G Castle, J Clase, P Grice, S Ley, C Pinel

Synlett

(1993)

1993

913

(doi: 10.1055/s-1993-22650)

TOTAL SYNTHESIS OF THE SPIROKETAL MACROLIDE (+) MILBEMYCIN ALPHA(1)

SV Ley, A Madin, NJT Monck

Tetrahedron Letters

(1993)

34

7479

(doi: 10.1016/S0040-4039(00)60158-2)

Microwave Promoted Hydrolysis of Esters Absorbed on Alumina: A New Deprotection Method for Pivaloyl Groups

S Ley*, D Mynett

Synlett

(1993)

1993

793

(doi: 10.1055/s-1993-22612)

SYNTHESIS OF 4-SUBSTITUTED IMIDAZOLES VIA 4-METALLO IMIDAZOLE INTERMEDIATES

R Turner*, S Ley, S Lindell

Synlett

(1993)

1993

748

(doi: 10.1055/s-1993-22594)

DISPIROKETALS IN SYNTHESIS .4. ENANTIOSELECTIVE DESYMMETRIZATION OF GLYCEROL USING A C2-SYMMETRICAL DISUBSTITUTED BIS-DIHYDROPYRAN

B Geert-Jan, DA Entwistle, SV Ley, M Woods

Tetrahedron Letters

(1993)

34

5649

(doi: 10.1016/S0040-4039(00)73906-2)

DISPIROKETALS IN SYNTHESIS .5. A NEW OPPORTUNITY FOR OLIGOSACCHARIDE SYNTHESIS USING DIFFERENTIALLY ACTIVATED GLYCOSYL DONORS AND ACCEPTORS

G-J Boons, P Grice, R Leslie, SV Ley, LL Yeung

Tetrahedron Letters

(1993)

34

8523

(doi: 10.1016/s0040-4039(00)61375-8)

Dispiroketals in Synthesis (Part 3):1 Selective Protection of Diequatorial Vicinal Diols in Carbohydrates

S Ley*, G-J Boons, R Leslie, M Woods, D Hollinshead

Synthesis

(1993)

1993

689

(doi: 10.1055/s-1993-25923)