Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Model studies towards the insect antifeedant Jodrellin A using an organoselenium mediated cyclization reaction
WM Blaney, AC Cuñat, SV Ley, FJ Montgomery, MSJ Simmonds
Tetrahedron Letters
(1994)
35
(doi: 10.1016/S0040-4039(00)76988-7)
Studies towards the total synthesis of rapamycin: A convergent and stereoselective synthesis of the C22C32 carbon framework
JC Anderson, SV Ley, SP Marsden
Tetrahedron Letters
(1994)
35
(doi: 10.1016/S0040-4039(00)73057-7)
STUDIES TOWARDS THE TOTAL SYNTHESIS OF RAPAMYCIN - PREPARATION OF THE C10-C17 CARBON UNIT
SV Ley, J Norman, C Pinel
Tetrahedron Letters
(1994)
35
(doi: 10.1016/s0040-4039(00)73059-0)
Studies towards the total synthesis of rapamycin: Preparation of the cyclohexyl C33C42 fragment and further coupling to afford the C22C42 carbon unit
C Kouklovsky, SV Ley, SP Marsden
Tetrahedron Letters
(1994)
35
(doi: 10.1016/s0040-4039(00)73058-9)
Towards the synthesis of the C37-C42 fragment of rapamycin: intramolecular reactions of allyl silanes with oxonium ions generated from α-alkoxy sulfones.
SV Ley, C Kouklovsky
Tetrahedron
(1994)
50
(doi: 10.1016/S0040-4020(01)80798-5)
Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)
G-J Boons, IC Lennon, SV Ley, ESE Owen, J Staunton, DJ Wadsworth
Tetrahedron Letters
(1994)
35
(doi: 10.1016/s0040-4039(00)76543-9)
BIOSYNTHESIS OF TETRONASIN .1. INTRODUCTION AND INVESTIGATION OF THE DIKETIDE AND TRIKETIDE INTERMEDIATES BOUND TO THE POLYKETIDE SYNTHASE
HC Hailes, CM Jackson, PF Leadlay, SV Ley, J Staunton
Tetrahedron Letters
(1994)
35
(doi: 10.1016/S0040-4039(00)76539-7)
Two new routes to the C19C26 tetrahydrofuran fragment of the acyl tetronic acid ionophore tetronasin (ICI M139603)
G-J Boons, DS Brown, JA Clase, IC Lennon, SV Ley
Tetrahedron Letters
(1994)
35
(doi: 10.1016/S0040-4039(00)76542-7)
BIOSYNTHESIS OF TETRONASIN .3. PREPARATION OF DEUTERIUM-LABELED TRIKETIDES AND TETRAKETIDES AS PUTATIVE BIOSYNTHETIC PRECURSORS OF TETRONASIN
HC Hailes, S Handa, PF Leadlay, IC Lennon, SV Ley, J Staunton
Tetrahedron Letters
(1994)
35
(doi: 10.1016/S0040-4039(00)76541-5)
BIOSYNTHESIS OF TETRONASIN .2. IDENTIFICATION OF THE TETRAKETIDE INTERMEDIATE ATTACHED TO THE POLYKETIDE SYNTHASE
HC Hailes, S Handa, PF Leadlay, IC Lennon, SV Ley, J Staunton
Tetrahedron Letters
(1994)
35
(doi: 10.1016/S0040-4039(00)76540-3)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge