Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
DISPIROKETALS IN SYNTHESIS .19. DISPIROKETALS AS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTIVE AGENTS FOR SYMMETRICAL CYCLIC AND ACYCLIC POLYOLS
Tetrahedron: Asymmetry
(1995)
6
2403
(doi: 10.1016/0957-4166(95)00318-j)
Dispiroketals in Synthesis (Part 18)1: Regioselective and Enantioselective Protection of Symmetric Polyol Substrates Using an Enantiopure (2S,2’S)-Dimethyl-bis-dihydropyran
Synlett
(1995)
1995
898
(doi: 10.1055/s-1995-5122)
SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1995)
210
24
Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications
Tetrahedron
(1995)
51
7755
(doi: 10.1016/0040-4020(95)00395-O)
The synthesis and assay of radiolabelled benzene derivatives
Tetrahedron
(1995)
51
7741
(doi: 10.1016/0040-4020(95)00394-N)
CYCLOHEXANE-1,2-DIACETALS IN SYNTHESIS .3. TUNING THE REACTIVITY OF GLYCOSIDES - EFFICIENT ONE-POT OLIGOSACCHARIDE SYNTHESIS
SYNLETT
(1995)
781
Tuning the Reactivity of Glycosides: Efficient One-pot Oligosaccharide Synthesis1
Synlett
(1995)
1995
781
(doi: 10.1055/s-1995-5052)
Chemistry of insect antifeedants from Azadirachta Indica (Part 19): 1A potential relay route for the synthesis of azadirachtin
Tetrahedron
(1995)
51
6591
(doi: 10.1016/0040-4020(95)00297-L)
Biosynthesis of tetronasin: Part 4, preparation of deuterium labelled C19-C26, C17-C26, C11-C26 and C3-C26 polyketide fragments as putative biosynthetic precursors of the ionophore antibiotic tetronasin (ICI 139603)
Tetrahedron
(1995)
51
5417
(doi: 10.1016/0040-4020(95)00201-i)
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