Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Dispiroketals in synthesis .20. Preparation of chiral 2,2'-bis(halomethyl) and 2,2'bis(phenylthiomethyl)dihydropyrans
Synlett
(1996)
1996
787
(doi: 10.1055/s-1996-5520)
Dispiroketals: a new functional group for organic synthesis
Journal of the Chemical Society Perkin Transactions 1
(1995)
2
365
(doi: 10.1039/CO9950200365)
Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimic
Bioorganic & Medicinal Chemistry Letters
(1995)
5
2637
(doi: 10.1016/0960-894x(95)00469-a)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN (SEPTEMBER, PG 898, 1995)
SYNLETT
(1995)
1196
10.1007/BF02383020
Entomologia experimentalis et applicata.
(1995)
77
69
Dispiroketals in synthesis (part 19)1: Dispiroketals as enantioselective and regioselective protective agents for symmetric cyclic and acyclic polyols.
Tetrahedron: Asymmetry
(1995)
6
2403
(doi: 10.1016/0957-4166(95)00318-j)
SOLID-PHASE SYNTHESIS OF BICYCLO[2.2.2]OCTANE DERIVATIVES VIA TANDEM MICHAEL ADDITION-REACTIONS AND SUBSEQUENT REDUCTIVE AMINATION
Synlett
(1995)
1995
1017
(doi: 10.1055/s-1995-5164)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN
Synlett
(1995)
1995
898
(doi: 10.1055/s-1995-5122)
SYNTHESIS AND CHEMISTRY OF THE INSECT ANTIFEEDANT AZADIRACHTIN
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1995)
210
24
Regiospecific fragmentation of benzene derivatives: synthetic and analytical applications
Tetrahedron
(1995)
51
7755
(doi: 10.1016/0040-4020(95)00395-O)
- ‹ previous
- Page 76
