Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents
– J CHEM SOC PERK T 1
(1999)
107
(doi: 10.1039/a809345h)
Rapid Assembly of Oligosaccharides: Total Synthesis of a Glycosylphosphatidylinositol Anchor of Trypanosoma brucei.
– Angew Chem Int Ed Engl
(1999)
37,
3423
Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in heart failure (CHF) treatment.: Effect on coronary microcircula-tion
– HYPERTENSION
(1999)
33,
1307
Prevalence of systemic hyprtension in morbid obesity.: Polysomnographic study.
– HYPERTENSION
(1999)
33,
1280
Chemistry of insect antifeedants from Azadirachta indica (Part 22): Functionalisation of the decalin fragment of azadirachtin via a Claisen rearrangement reaction
– Synlett
(1999)
1999,
1295
(doi: 10.1055/s-1999-2802)
Clean synthesis of a-bromo ketones and their utilisation in the synthesis of 2-aIkoxy-2,3-dihydro-2-aryl-l,4-benzodioxanes, 2-amino-4-aryI-l,3-thiazoles and piperidino-2-amino-l,3-thiazoles using polymer-supported reagents
– Journal of the Chemical Society Perkin Transactions 1
(1999)
2425
(doi: 10.1039/a905616e)
Prevalence of systemic hypertension in morbid obesity.: Polysomnographic study.
– HYPERTENSION
(1999)
33,
1076
Recent studies on the use of MPA and MTPA in the determination of the absolute configuration of secondary alcohols by 1H NMR
– Chemtracts
(1999)
12,
539
Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents
– Journal of the Chemical Society Perkin Transactions 1
(1999)
1253
(doi: 10.1039/a901802f)
Nitrogen atom transfer from a novel nitridomanganese complex for the amination of silyl enol ether and glycal derivatives
– Chemtracts
(1999)
12,
27
- <
- 73 of 108