Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Highly cis - or trans -selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers

DJ Dixon, SV Ley, EW Tate

Journal of the Chemical Society, Perkin Transactions 1

(1999)

2665

(doi: 10.1039/a904891j)

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

J Habermann, SV Ley, R Smits

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1999)

2421

(doi: 10.1039/a904384e)

Total synthesis of the cholesterol biosynthesis inhibitor 1233A via a (π-allyl)tricarbonyliron lactone complex

RW Bates, E Fernández-Megía, SV Ley, K Rück-Braun, DMG Tilbrook

J CHEM SOC PERK T 1

(1999)

1917

(doi: 10.1039/a903641e)

Preparation of desymmetrised meso-tartrate derivatives-synthesis and utility of (R,R,R,S)-2,3-butane diacetal protected dimethyl tartrate

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

J CHEM SOC PERK T 1

(1999)

1631

(doi: 10.1039/a902733e)

A general and efficient procedure for the preparation of enantiopure anti-1,2-diols -: synthesis and utility of (R′,R′,S,R)-2,3-butane diacetal protected butane tetrol

DJ Dixon, AC Foster, SV Ley, DJ Reynolds

J CHEM SOC PERK T 1

(1999)

1635

(doi: 10.1039/a902732g)

Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents

J Habermann, SV Ley, JS Scott

Journal of the Chemical Society Perkin Transactions 1

(1999)

1253

(doi: 10.1039/a901802f)

Synthesis of the alkaloids (+/-)-oxomaritidine and (+/-)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents

SV Ley, O Schucht, AW Thomas, PJ Murray

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1999)

1251

(doi: 10.1039/a901798d)

Dispiroketals in synthesis. Part 25.1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

M Fujita, D Lainé, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1999)

1647

(doi: 10.1039/a900951e)

Dispiroketals in synthesis. Part 24.1 Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

D Lainé, M Fujita, SV Ley

J CHEM SOC PERK T 1

(1999)

1639

(doi: 10.1039/a900950g)

Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine†

DJ Dixon, SV Ley, T Gracza, P Szolcsanyi

Journal of the Chemical Society Perkin Transactions 1

(1999)

839

(doi: 10.1039/a809823i)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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