Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

1,7-Induction of chirality in Mukaiyama aldol reactions using π- allyltricarbonyliron lactone and lactam complexes as chiral templates

SV Ley, LR Cox, B Middleton, JM Worrall

Tetrahedron

(1999)

3515

(doi: 10.1016/s0040-4020(98)01159-4)

Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents

M Caldarelli, J Habermann, SV Ley

J CHEM SOC PERK T 1

(1999)

107

(doi: 10.1039/a809345h)

Rapid assembly of oligosaccharides: Total synthesis of a glycosylphosphatidylinositol anchor of Trypanosoma brucei

DK Baeschlin, AR Chaperon, V Charbonneau, LG Green, SV Ley, U Lücking, E Walther

Angewandte Chemie (International ed. in English)

(1999)

3423

(doi: 10.1002/(SICI)1521-3773(19981231)37:24<3423::AID-ANIE3423>3.0.CO;2-I)

Polymer-supported hypervalent iodine reagents in 'clean' organic synthesis with potential application in combinatorial chemistry

SV Ley, AW Thomas, H Finch

J CHEM SOC PERK T 1

(1999)

669

(doi: 10.1039/a809799b)

Total synthesis of the polyenoyltetramic acid mycotoxin erythroskyrine †

DJ Dixon, SV Ley, T Gracza, P Szolcsanyi

Journal of the Chemical Society, Perkin Transactions 1

(1999)

839

(doi: 10.1039/a809823i)

Spect Tc 99m sestamibi in the evaluation of an an-tihypertensive drug (carvedilol) in the heart failure (CHF) treatment, effect on coronary microcircula-tion

V Rebollar, Orea, M Fernández, J Dorantes, C Keirns, J Oseguera, A Rangel, J Sepulveda, S Ley, X Gómez, R Navarrete, T Sánchez, O González

HYPERTENSION

(1999)

1088

Dispiroketals in synthesis. Part 24.1 Preparation and use of chiral 2,2′-bis(triisopropylsilyloxymethyl)bi(dihydropyran)s as new protecting and resolving agents for 1,2-diols

D Lainé, M Fujita, SV Ley

Journal of the Chemical Society, Perkin Transactions 1

(1999)

1639

(doi: 10.1039/a900950g)

Dispiroketals in synthesis. Part 25.1 Further reactions of dispiroketal protected glycolate to afford optically active 1,2,3,4-tetraols

M Fujita, D Lainé, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1999)

1647

(doi: 10.1039/a900951e)

Synthesis of the alkaloids (+/-)-oxomaritidine and (+/-)-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents

SV Ley, O Schucht, AW Thomas, PJ Murray

Journal of the Chemical Society Perkin Transactions 1

(1999)

1251

(doi: 10.1039/a901798d)

Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents

J Habermann, SV Ley, JS Scott

Journal of the Chemical Society Perkin Transactions 1

(1999)

1253

(doi: 10.1039/a901802f)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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