Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol

SV Ley, S Burckhardt

J CHEM SOC PERK T 1

(2000)

3028

(doi: 10.1039/b005942k)

The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahyclropyranyl ether derivatives

DJ Dixon, SV Ley, EW Tate

Journal of the Chemical Society Perkin Transactions 1

(2000)

1829

(doi: 10.1039/a909302h)

A short stereoselective total synthesis of the fusarium toxin equisetin.

LT Burke, DJ Dixon, SV Ley, F Rodríguez

Org Lett

(2000)

2

3611

(doi: 10.1021/ol006493u)

The total synthesis of the annonaceous acetogenin, muricatetrocin C

DJ Dixon, SV Ley, DJ Reynolds

Angewandte Chemie International Edition

(2000)

39

3622

(doi: 10.1002/1521-3773(20001016)39:20<3622::aid-anie3622>3.0.co;2-h)

Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing α-1,3-fucosyltransferase V

A Düffels, LG Green, R Lenz, SV Ley, SP Vincent, CH Wong

Bioorganic & medicinal chemistry

(2000)

8

2519

(doi: 10.1016/s0968-0896(00)00187-5)

Polymer-supported reagents for multi-step organic synthesis: Application to the synthesis of sildenafil

IR Baxendale, SV Ley

Bioorganic & Medicinal Chemistry Letters

(2000)

10

1983

(doi: 10.1016/s0960-894x(00)00383-8)

Combined application of analytical techniques for the characterization of polymer supported species

P Grice, AG Leach, SV Ley, A Massi, DM Mynett

Journal of combinatorial chemistry

(2000)

2

491

(doi: 10.1021/cc000021p)

Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic probes for glycosyltransferases.

MD Burkart, SP Vincent, A Düffels, BW Murray, SV Ley, CH Wong

Bioorg Med Chem

(2000)

8

1937

(doi: 10.1016/s0968-0896(00)00139-5)

Protecting groups: Effects on reactivity, glycosylation stereoselectivity, and coupling efficiency

LG Green, SV Ley, B Ernst, GW Hart, P Sinaý

(2000)

1-4

427

(doi: 10.1002/9783527618255.ch17)

Synthesis of high-mannose type neoglycolipids: Active targeting of liposomes to macrophages in gene therapy

A Düffels, LG Green, SV Ley, AD Miller

Chemistry A European Journal

(2000)

6

1416

(doi: 10.1002/(sici)1521-3765(20000417)6:8<1416::aid-chem1416>3.0.co;2-o)