Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry
(2001)
40
1043
Data mining and the future of chemistry
MANUFACTURING CHEMIST
(2001)
72
14
Looking to the future
CHEMISTRY IN BRITAIN
(2001)
37
24
1,2-diacetals: A new opportunity for organic synthesis
Chemical Reviews
(2000)
101
53
(doi: 10.1021/cr990101j)
A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis
Synlett
(2000)
2000
1603
(doi: 10.1055/s-2000-7917)
Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: an investigation of the reaction mechanism via a double isotopic labelling crossover study
Journal of the Chemical Society Perkin Transactions 1
(2000)
1815
(doi: 10.1039/a909300a)
1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using π-allyltricarbonyliron lactone complexes: Highly diastereoselective synthesis of π-substituted β-hydroxy carbonyl compounds
Journal of the Chemical Society, Perkin Transactions 1
(2000)
1677
(doi: 10.1039/b002056g)
Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-(S,S)-(cis-6-methyltetrahydropyran-2-yl)acetic acid, a component of civet
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2000)
2385
(doi: 10.1039/b001243m)
Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]
Organic Syntheses
(2000)
77
212
Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation
Journal of the Chemical Society Perkin Transactions 1
(2000)
3815
(doi: 10.1039/b006588i)
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