Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Peterson olefination using phenylsulphonyltrimethylsilylmethane. A new preparation of vinylic sulphones
– Journal of the Chemical Society, Chemical Communications
(1983)
1281
(doi: 10.1039/c39830001281)
Synthesis of the drimane-related sesquiterpenes euryfuran, confertifolin, and valdiviolide
– J CHEM SOC PERK T 1
(1983)
1379
(doi: 10.1039/p19830001379)
The Diels-Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin and warburganal
– J CHEM SOC PERK T 1
(1983)
1579
(doi: 10.1039/p19830001579)
Total synthesis of the structurally unique ionophore antibiotic X-14547 A
– Journal of the Chemical Society, Chemical Communications
(1983)
630
(doi: 10.1039/C39830000630)
Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids
– Tetrahedron Letters
(1983)
24,
5143
Dehydrogenation of lactones using benzeneseleninic anhydride. X-ray crystal structure of 3β-acetoxy-14α-hydroxy-17a-oxa-D-homo-5α-androst- 15-en-17-one
– J CHEM SOC PERK T 1
(1982)
1919
(doi: 10.1039/p19820001919)
A short syntesis of (±)-hirsutene involving the use of an organoselenium-mediated cyclization reaction
– Chemical Communications
(1982)
1252
(doi: 10.1039/C39820001252)
A conformational study of elaiophylin by X-ray crystallography and difference 1H NMR methods; observation of a selective sign reversal of the nuclear overhauser effect
– Tetrahedron Letters
(1982)
23,
1207
Synthesis of polyoxygenated trans -decalins as potential insect antifeedants
– J CHEM SOC PERK T 1
(1982)
2157
(doi: 10.1039/p19820002157)
SYNTHESIS OF METHYL-1,6-DIOXASPIRO[4,5]DECANES USING ORGANOSELENIUM MEDIATED CYCLIZATION REACTIONS
– Tetrahedron Letters
(1982)
23,
4625
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