Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
WITTIG AND HORNER-WITTIG COUPLING REACTIONS OF 2-SUBSTITUTED CYCLIC ETHERS AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
Tetrahedron
(1985)
41
3825
Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex
Tetrahedron
(1985)
41
5871
THE USE OF "3-ACETOXY-1-TRIMETHYLSILYLBUTADIENE IN THE SYNTHESIS OF ANTHRACYCLINONE DERIVATIVES
J CHEM SOC PERK T 1
(1984)
1847
(doi: 10.1039/p19840001847)
Novel rearrangement of the ionophore antibiotic X-14547A (indanomycin) and related derivatives induced by lithium tetrafluoroborate
J CHEM SOC PERK T 1
(1984)
1761
(doi: 10.1039/p19840001761)
Synthesis of spiroacetals using organoselenium-mediated cyclisation reactions. X-Ray molecular structure of (2S,8R)-8-methyl-2-phenyl-1,7- dioxaspiro-[5.5]undecan-4(R)-ol
J CHEM SOC PERK T 1
(1984)
1371
(doi: 10.1039/p19840001371)
A new route to spiro-ketals using the Horner-Wittig reaction of 2-diphenylphosphinoxy cyclic ethers
Tetrahedron Letters
(1984)
25
113
Oxo complexes of ruthenium(VI) and (VII) as organic oxidants
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1984)
681
(doi: 10.1039/p19840000681)
Synthesis of the spiroacetal unit related to the avermectins and milbemycins
Journal of the Chemical Society, Chemical Communications
(1984)
1381
(doi: 10.1039/c39840001381)
Fe2(co)g in tetrahydrofuran or under sonochemical conditions as convenient practical routes to π-allyltricarbonyliron lactone complexes
Tetrahedron
(1984)
40
1737
Synthesis of (±)-cis-6-methyltetrahydropyran-2-ylacetic acid, a natural product from Viverra civetta, using organoselenium-mediated cyclisation reactions
J. Chem. Soc., Perkin Trans. 1
(1984)
2403
(doi: 10.1039/p19840002403)
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