Professor Steve Ley CBE FRS FMedSci | Page 94 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Preparation of acyltetronic acids using t-butyl acetothioacetate: Total synthesis of the fungal metabolites carolic, carlosic, and carlic acids

PM BOOTH, CMJ FOX, SV LEY

– Journal of the Chemical Society, Perkin Transactions 1

(1987)

121

(doi: 10.1039/p19870000121)

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

SV LEY, D SANTAFIANOS, WM BLANEY, MSJ SIMMONDS

– Tetrahedron Letters

(1987)

28,

221

(doi: 10.1016/s0040-4039(00)95691-0)

A CONFORMATIONAL STUDY OF BAFILOMYCIN-A1 BY X-RAY CRYSTALLOGRAPHY AND NMR TECHNIQUES

GH BAKER, PJ BROWN, RJJ DORGAN, JR EVERETT, SV LEY, AMZ SLAWIN, DJ WILLIAMS

– Tetrahedron Letters

(1987)

28,

5565

(doi: 10.1016/s0040-4039(00)96783-2)

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

SV Ley, D Santafianos, WM Blaney, MSJ Simmonds

– Tetrahedron Letters

(1987)

28,

1595

(doi: 10.1016/S0040-4039(00)95369-3)

DEVELOPMENT OF A SYNTHETIC ROUTE TOWARDS MILBEMYCIN-BETA-1 - PREPARATION OF AN ADVANCED MODEL SYSTEM

NJ ANTHONY, P GRICE, SV LEY

– Tetrahedron Letters

(1987)

28,

5763

(doi: 10.1016/S0040-4039(00)96835-7)

PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES

SV LEY, PR WOODWARD

– Tetrahedron Letters

(1987)

28,

345

(doi: 10.1016/S0040-4039(00)95725-3)

Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues

T CLARKE, SV LEY

– Journal of the Chemical Society, Perkin Transactions 1

(1987)

131

(doi: 10.1039/p19870000131)

Application of ultrasound to the preparation of tricarbonyliron diene complexes

SV LEY, CMR LOW, AD WHITE

– Journal of Organometallic Chemistry

(1986)

302,

C13

(doi: 10.1016/0022-328X(86)80072-9)

Synthestic approaches to the teleocidin-related tumour promoters: a total synthesis of (±)-indolactam V

SE DELASZLO, SV LEY, RA PORTER

– Journal of the Chemical Society, Chemical Communications

(1986)

344

(doi: 10.1039/c39860000344)

Ultrasonic formation and reactions of sodium phenylselenide

SV LEY, IA ONEIL, CMR LOW

– Tetrahedron

(1986)

42,

5363

(doi: 10.1016/s0040-4020(01)82086-x)