Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
J CHEM SOC PERK T 1
(1987)
121
(doi: 10.1039/p19870000121)
Preparation of t-butyl 4-diethylphosphono-3-oxobutanethioate and use in the synthesis of (E)-4-alkenyl-3-oxoesters and macrolides
Tetrahedron Letters
(1987)
28
345
The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides
Tetrahedron Letters
(1987)
28
3019
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
Tetrahedron Letters
(1987)
28
1595
A CONFORMATIONAL STUDY OF BAFILOMYCIN-A1 BY X-RAY CRYSTALLOGRAPHY AND NMR TECHNIQUES
Tetrahedron Letters
(1987)
28
5565
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
Tetrahedron
(1987)
43
2805
Application of ultrasound to the preparation of tricarbonyliron diene complexes
Journal of Organometallic Chemistry
(1986)
302
C13
(doi: 10.1016/0022-328X(86)80072-9)
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
Tetrahedron
(1986)
42
3723
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
Tetrahedron
(1986)
42
6519
Ultrasonic formation and reactions of sodium phenylselenide
Tetrahedron
(1986)
42
5363
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