Professor Steve Ley CBE FRS FMedSci | Page 10 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

The Generation of a Library of Bromodomain-Containing Protein Modulators Expedited by Continuous Flow Synthesis

P Filipponi, IR Baxendale

– European Journal of Organic Chemistry

(2016)

2016,

2000

(doi: 10.1002/ejoc.201600222)

Enabling Technologies for the Future of Chemical Synthesis

DE Fitzpatrick, C Battilocchio, SV Ley

– ACS Cent Sci

(2016)

2,

131

(doi: 10.1021/acscentsci.6b00015)

Iterative reactions of transient boronic acids enable sequential C-C bond formation

C Battilocchio, F Feist, A Hafner, M Simon, DN Tran, DM Allwood, DC Blakemore, SV Ley

– Nat Chem

(2016)

8,

360

(doi: 10.1038/NCHEM.2439)

Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry.

D Lücke, T Dalton, SV Ley, ZE Wilson

– Chemistry A European Journal

(2016)

22,

4206

(doi: 10.1002/chem.201504457)

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process.

J-S Poh, DL Browne, SV Ley

– Reaction Chemistry & Engineering

(2016)

1,

101

(doi: 10.1039/c5re00082c)

Welcome to Reaction Chemistry & Engineering

SA Khan, IR Baxendale, JM Hawkins, SV Ley, K Jensen, V Hessel, G Luo, D Blackmond, A Katz, DG Vlachos, ME Davis

– Reaction Chemistry & Engineering

(2016)

1,

8

(doi: 10.1039/c6re90001a)

Controlled generation and use of CO in flow (vol 1, pg 280, 2016)

SVF Hansen, ZE Wilson, T Ulven, SV Ley

– Reaction Chemistry & Engineering

(2016)

1,

340

(doi: 10.1039/c6re90010k)

Editorial-Flow Chemistry and Catalysis

SV Ley

– Catalysis Science & Technology

(2016)

6,

4676

(doi: 10.1039/c6cy90064j)

Flow enabled peptide synthesis

Z Wilson, S Ley

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2016)

252,

(link to publication)

Continuous photochemistry: The flow synthesis of ibuprofen: Via a photo-Favorskii rearrangement

M Baumann, IR Baxendale

– Reaction Chemistry & Engineering

(2016)

1,

147

(doi: 10.1039/c5re00037h)