Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
INSECT ANTIFEEDANTS
CHEM BRIT
(1990)
26
31
INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .5. CHEMICAL MODIFICATION AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF AZADIRACHTIN AND SOME RELATED LIMONOIDS
Tetrahedron
(1989)
45
5175
The first crystal and molecular structure of lanthanide homodinuclear macrocyclic complexes showing metal–metal pair interactions
J. Chem. Soc., Chem. Commun.
(1989)
1531
(doi: 10.1039/c39890001531)
The antifeedant activity of clerodane diterpenoids from Teucrium
Phytochemistry
(1989)
28
1069
(doi: 10.1016/0031-9422(89)80184-0)
SUBSTITUTION-REACTIONS OF 2-BENZENESULFONYL CYCLIC ETHERS WITH SILYL ENOL ETHERS PROMOTED BY ALUMINUM TRICHLORIDE
Heterocycles
(1989)
28
773
(doi: 10.3987/com-88-s145)
ASSEMBLY OF THE T-CELL RECEPTOR CD3 COMPLEX
PROGRESS IN IMMUNOLOGY, VOL 7
(1989)
33
Chemistry of insect antifeedants from azadirachta indica (part 4): synthesis towards the limonoid azadirachtin; preparation of a functionalised decalin fragment
Tetrahedron
(1989)
45
2143
Microbial Oxidation in Synthesis: Preparation of (+)- and (−)-Pinitol from Benzene
Tetrahedron
(1989)
45
3463
THE STRUCTURE OF 2 NEW CLERODANE DITERPENOID POTENT INSECT ANTIFEEDANTS FROM SCUTELLARIA-WORONOWII (JUZ) - JODRELLIN-A AND JODRELLIN-B
Tetrahedron Letters
(1989)
30
4737
Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene
Tetrahedron Letters
(1989)
30
3557
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