Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Chemistry of insect antifeedants from Azadirachta indica, Part 14: absolute configuration of azadirachtin
– Chemical Communications
(1992)
1304
(doi: 10.1039/c39920001304)
TOTAL SYNTHESIS OF THE IONOPHORE ANTIBIOTIC CP-61,405 (ROUTIENNOCIN)
– Tetrahedron
(1992)
48,
7899
DISPIROKETALS IN SYNTHESIS .2. A NEW GROUP FOR THE SELECTIVE PROTECTION OF DIEQUATORIAL VICINAL DIOLS IN CARBOHYDRATES
– Tetrahedron Letters
(1992)
33,
4767
Oxidation of Activated Halides to Aldehydes and Ketones by N-Methylmorpholine-N-oxide
– Synthetic Communications
(1992)
22,
1967
(doi: 10.1080/00397919208021328)
Total Synthesis of the Carboxylic Acid Ionophore Antibiotic CP-61,405 (Routiennocin)
– Synlett
(1992)
1992,
395
(doi: 10.1055/s-1992-21357)
Total Synthesis of the Carboxylic Acid lonophore Antibiotic CP-61,405 (Routiennocin): Preparation of the Inherent Spiroketal Unit via a Reverse Coupling Process
– Synlett
(1992)
1992,
399
(doi: 10.1055/s-1992-21358)
Microbial Oxidation in Synthesis: Preparation of Pseudo-α-D-glucopyranose from Benzene
– Synlett
(1992)
1992,
291
(doi: 10.1055/s-1992-21342)
Further reactions of t-butyl 3-oxobutanthioate and t-butyl 4-diethyl-phosphono-3-oxobutanthioate : Carbonyl coupling reactions, amination, use in the preparation of 3-acyltetramic acids and application to the total synthesis of fuligorubin A.
– Tetrahedron
(1992)
48,
1145
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