Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Microwave promoted hydrolysis of esters absorbed on alumina: A new deprotection method for pivaloyl groups
– Synlett
(1993)
1993,
793
(doi: 10.1055/s-1993-22612)
DISPIROKETALS IN SYNTHESIS .4. ENANTIOSELECTIVE DESYMMETRIZATION OF GLYCEROL USING A C2-SYMMETRICAL DISUBSTITUTED BIS-DIHYDROPYRAN
– Tetrahedron Letters
(1993)
34,
5649
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .15. DEGRADATION STUDIES OF AZADIRACHTIN LEADING TO C8-C-14 BOND-CLEAVAGE
– Tetrahedron
(1993)
49,
1675
Dispiroketals in Synthesis (Part 3):1 Selective Protection of Diequatorial Vicinal Diols in Carbohydrates
– Synthesis
(1993)
1993,
689
(doi: 10.1055/s-1993-25923)
Some Alkylation and Reductive Amination Studies of b-Ketomacrolides as Potential Metal Speciation Materials
– Heterocycles
(1993)
35,
263
(doi: 10.3987/com-92-s12)
UPTAKE, RETENTION, METABOLISM AND EXCRETION OF [22,23-H-3(2)]DIHYDROAZADIRACHTIN IN SCHISTOCERCA-GREGARIA
– Journal of Insect Physiology
(1993)
39,
935
(doi: 10.1016/0022-1910(93)90003-a)
Microbial Oxidation in Synthesis: Preparation of a Potential Insulin Mimic from Benzene
– Synlett
(1992)
1992,
997
(doi: 10.1055/s-1992-21561)
Alfred bader [2]
– Chemical and Engineering News
(1992)
70,
2
Chemistry of insect antifeedants from azadirachta indica (Part 12): Use of silicon as a control element in the synthesis of a highly functionalized decalin fragment of azadirachtin
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1992)
2735
(doi: 10.1039/p19920002735)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .14. ABSOLUTE-CONFIGURATION OF AZADIRACHTIN
– Journal of the Chemical Society Chemical Communications
(1992)
1304
(doi: 10.1039/C39920001304)
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