Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
DISPIROKETALS IN SYNTHESIS .6. HIGHLY STEREOSELECTIVE ALKYLATION OF DISPIROKETAL PROTECTED LACTATE AND GLYCOLATE ENOLATES
– Tetrahedron Letters
(1994)
35,
769
Dispiroketals in synthesis (part 7): Protection of D-glucopyranose substrates
– Tetrahedron Letters
(1994)
35,
773
Towards the synthesis of the C37-C42 fragment of rapamycin: intramolecular reactions of allyl silanes with oxonium ions generated from α-alkoxy sulfones.
– Tetrahedron
(1994)
50,
835
NOVEL POLYENE CYCLIZATION ROUTES TO THE ACYL TETRONIC ACID IONOPHORE TETRONASIN (ICI M139603)
– Tetrahedron Letters
(1994)
35,
323
2 NEW ROUTES TO THE C19-C26 TETRAHYDROFURAN FRAGMENT OF THE ACYL TETRONIC ACID IONOPHORE TETRONASIN (ICI M139603)
– Tetrahedron Letters
(1994)
35,
319
BIOSYNTHESIS OF TETRONASIN .1. INTRODUCTION AND INVESTIGATION OF THE DIKETIDE AND TRIKETIDE INTERMEDIATES BOUND TO THE POLYKETIDE SYNTHASE
– Tetrahedron Letters
(1994)
35,
307
BIOSYNTHESIS OF TETRONASIN .3. PREPARATION OF DEUTERIUM-LABELED TRIKETIDES AND TETRAKETIDES AS PUTATIVE BIOSYNTHETIC PRECURSORS OF TETRONASIN
– Tetrahedron Letters
(1994)
35,
315
Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase
– Tetrahedron Letters
(1994)
35,
311
Tetrapropylammonium Perruthenate, Pr4N+RuO4 -, TPAP: A Catalytic Oxidant for Organic Synthesis
– Synthesis
(1994)
1994,
639
(doi: 10.1055/s-1994-25538)
DISPIROKETALS IN SYNTHESIS .15. SIMULTANEOUS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTION OF GLYCEROL BY REACTION WITH C-2 SYMMETRICAL (4S,4'S)-DIMETHYL-BIS-DIHYDROPYRAN
– Synthesis
(1994)
1994,
1275
(doi: 10.1055/s-1994-25680)
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