Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Continuous Processing and Efficient $\textit{in Situ}$ Reaction Monitoring of a Hypervalent Iodine(III) Mediated Cyclopropanation Using Benchtop NMR Spectroscopy
– Organic Process Research & Development
(2016)
20,
1603
(doi: 10.1021/acs.oprd.6b00177)
The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B.
– Chemistry – A European Journal
(2016)
22,
15902
(doi: 10.1002/chem.201603157)
Taming hazardous chemistry by continuous flow technology
– Chemical Society reviews
(2016)
45,
4892
(doi: 10.1039/c5cs00902b)
A multicomponent approach for the preparation of homoallylic alcohols
– Chem Sci
(2016)
7,
6803
(doi: 10.1039/c6sc02581a)
Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation
– Organic & Biomolecular Chemistry
(2016)
14,
5983
(doi: 10.1039/c6ob00970k)
Identification and Development of 2,3-Dihydropyrrolo[1,2‑a]quinazolin-5(1H)‑one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex
– J Med Chem
(2016)
59,
5095
(doi: 10.1021/acs.jmedchem.5b01997)
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
– ACS Sustainable Chemistry and Engineering
(2016)
4,
1912
Solvent-Free Continuous Operations Using Small Footprint Reactors: A Key Approach for Process Intensification
– ACS Sustainable Chemistry & Engineering
(2016)
4,
1912
Development of the industrial synthesis of vitamin A
– Tetrahedron
(2016)
72,
1645
(doi: 10.1016/j.tet.2016.02.029)
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