Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Diastereoselective addition reactions of allylstannanes to carbonyl groups in the side-chain of pi-allyltricarbonyliron lactone complexes
– Chemical Communications
(1996)
657
(doi: 10.1039/cc9960000657)
Dispiroketals in Synthesis (Part 22)1: Use of Chiral 2,2′-Bis(phenylthiomethyl)-dihydropyrans as New Protecting and Resolving Agents for 1,2-Diols
– Synlett
(1996)
1996,
791
(doi: 10.1055/s-1996-5522)
Direct protection of 1,2-diols from alpha-diketones
– Synlett
(1996)
1996,
793
(doi: 10.1055/s-1996-5523)
Dispiroketals in Synthesis (Part 21)1: Use of Chiral 2,2′-Bis(halomethyl)dihydropyrans as New Protecting and Resolving Agents for 1,2-Diols
– Synlett
(1996)
1996,
789
(doi: 10.1055/s-1996-5521)
Autoradiographic localization of [22,23-3H2] dihydroazadirachtin binding sites in desert locust testes and effects of Azadirachtin on sperm motility
– Tissue and Cell
(1996)
28,
725
Dispiroketals: A new functional group for organic synthesis
– Contemporary Organic Synthesis
(1995)
2,
365
(doi: 10.1039/CO9950200365)
Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimic
– Bioorganic & Medicinal Chemistry Letters
(1995)
5,
2637
(doi: 10.1016/0960-894X(95)00469-A)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN (SEPTEMBER, PG 898, 1995)
– SYNLETT
(1995)
1196
Solid Phase Synthesis of Bicyclo[22.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination
– Synlett
(1995)
1995,
1017
(doi: 10.1055/s-1995-5164)
DISPIROKETALS IN SYNTHESIS .19. DISPIROKETALS AS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTIVE AGENTS FOR SYMMETRICAL CYCLIC AND ACYCLIC POLYOLS
– Tetrahedron Asymmetry
(1995)
6,
2403
(doi: 10.1016/0957-4166(95)00318-j)
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