Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthetic studies towards the clerodane insect antifeedant jodrellin A: Preparation of a polycyclic model compound with antifeedant activity
J CHEM SOC PERK T 1
(1996)
611
(doi: 10.1039/p19960000611)
Diastereoselective additions to aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes
Chemical Communications
(1996)
317
(doi: 10.1039/CC9960000317)
Dispiroketals: a new functional group for organic synthesis
Journal of the Chemical Society Perkin Transactions 1
(1995)
2
365
(doi: 10.1039/co9950200365)
Spiroketal glycomimetics: the synthesis of a conformationally restrained Sialyl Lewis X mimic
Bioorganic & Medicinal Chemistry Letters
(1995)
5
2637
(doi: 10.1016/0960-894X(95)00469-A)
DISPIROKETALS IN SYNTHESIS .18. REGIOSELECTIVE AND ENANTIOSELECTIVE PROTECTION OF SYMMETRICAL POLYOL SUBSTRATES USING AN ENANTIOPURE (2S,2'S)-DIMETHYL-BIS-DIHYDROPYRAN (SEPTEMBER, PG 898, 1995)
SYNLETT
(1995)
1196
DISPIROKETALS IN SYNTHESIS .19. DISPIROKETALS AS ENANTIOSELECTIVE AND REGIOSELECTIVE PROTECTIVE AGENTS FOR SYMMETRICAL CYCLIC AND ACYCLIC POLYOLS
Tetrahedron: Asymmetry
(1995)
6
2403
(doi: 10.1016/0957-4166(95)00318-j)
Behavioural and neurophysiological responses of Spodoptera littoralis to azadirachtin and a range of synthetic analogues.
Entomologia experimentalis et applicata.
(1995)
77
69
Solid Phase Synthesis of Bicyclo[2.2.2]octane Derivatives via Tandem Michael Addition Reactions and Subsequent Reductive Amination
Synlett
(1995)
1995
1017
(doi: 10.1055/s-1995-5164)
Dispiroketals in Synthesis (Part 18)1: Regioselective and Enantioselective Protection of Symmetric Polyol Substrates Using an Enantiopure (2S,2’S)-Dimethyl-bis-dihydropyran
Synlett
(1995)
1995
898
(doi: 10.1055/s-1995-5122)
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