Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Molybdenum(II)-catalyzed allylic substitution
– Tetrahedron Letters
(1997)
38,
4895
Polymer supported perruthenate (PSP): a new oxidant for clean organic synthesis
– Journal of the Chemical Society Perkin Transactions 1
(1997)
1907
(doi: 10.1039/a703461j)
Synthesis of beta-dimorphecolic acid exploiting highly stereoselective reduction of a side-chain carbonyl group in a pi-allyltricarbonyliron lactone complex
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1997)
1125
(doi: 10.1039/a607376j)
Synthesis and chemistry of dispiroacetals and other 1,2-diacetals.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1997)
213,
33
Dispiroketals in synthesis. Part 23.1 A new route to (+)-D-conduritol B from myo-inositol
– Journal of the Chemical Society Perkin Transactions 1
(1997)
795
(doi: 10.1039/a700422b)
Preparation, structure, derivatisation and NMR data of cyclohexane-1,2-diacetal protected carbohydrates
– Journal of the Chemical Society - Perkin Transactions 1
(1997)
351
(doi: 10.1039/a605851e)
Autoradiographic localization of [22, 23-H-3(2)] dihydroazadirachtin binding sites in desert locust testes and effects of azadirachtin on sperm motility (vol 28, pg 725, 1996)
– TISSUE CELL
(1997)
29,
129
A general C-glycosidation procedure via anomeric oxygen to carbon rearrangements of tetrahydropyranyl ether derivatives
– Synlett
(1997)
1997,
1055
(doi: 10.1055/s-1997-1531)
One-Pot Synthesis of Tetra- and Pentasaccharides from Monomeric Building Blocks Using the Principles of Orthgonality and Reactivity Tuning
– Synlett
(1997)
1997,
257
(doi: 10.1055/s-1997-765)
Identification of azadirachtin in tissue-cultured cells of Neem (Azadirachta indica)
– Natural Product Letters
(1997)
10,
95
(doi: 10.1080/10575639708043721)
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