Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Chemistry of insect antifeedants from Azadirachta indica (part 20): synthesis of biologically active, simple analogues of azadirachtin, containing the hydroxytetrahydrofurancarboxylate hemiketal moiety

ML de la Puente, RB Grossman, SV Ley, MSJ Simmonds, WM Blaney

Journal of the Chemical Society Perkin Transactions 1

(1996)

1517

(doi: 10.1039/p19960001517)

Chemistry of insect antifeedants from Azadirachta indica (part 21): synthesis of model compounds of azadirachtin using a decalin framework as a functional group scaffolding

ML de la Puente, SV Ley, MSJ Simmonds, WM Blaney

Journal of the Chemical Society, Perkin Transactions 1

(1996)

1523

(doi: 10.1039/p19960001523)

(π-Allyl)tricarbonyliron lactone complexes in organic synthesis: A useful and conceptually unusual route to lactones and lactams

SV Ley, LR Cox, G Meek

Chemical reviews

(1996)

423

(doi: 10.1021/cr950015t)

Dispiroketals in Synthesis (Part 21)1: Use of Chiral 2,2′-Bis(halomethyl)dihydropyrans as New Protecting and Resolving Agents for 1,2-Diols

S Ley*, S Mio

Synlett

(1996)

1996

789

(doi: 10.1055/s-1996-5521)

Dispiroketals in synthesis .22. Use of chiral 2,2'-bis(phenylthiomethyl)-dihydropyrans as new protecting and resolving agents for 1,2-diols

S Ley*, S Mio, B Meseguer

Synlett

(1996)

1996

791

(doi: 10.1055/s-1996-5522)

Direct protection of 1,2-diols from alpha-diketones

N Douglas, S Ley*, H Osborn, D Owen, H Priepke, S Warriner

Synlett

(1996)

1996

793

(doi: 10.1055/s-1996-5523)

Synthetic studies towards the clerodane insect antifeedant jodrellin A: Preparation of a polycyclic model compound with antifeedant activity

AC Cuñat, D Díez-Martín, SV Ley, FJ Montgomery

J CHEM SOC PERK T 1

(1996)

611

(doi: 10.1039/P19960000611)

Autoradiographic localization of [22,23-(3)H(2)] dihydroazadirachtin binding sites in desert locust testes and effects of Azadirachtin on sperm motility.

AJ Nisbet, AJ Mordue Luntz, LM Williams, L Hannah, L Jennens, SV Ley, W Mordue

Tissue & cell

(1996)

725

(doi: 10.1016/s0040-8166(96)80075-9)

Diastereoselective additions to aldehyde groups in the side-chain of π-allyltricarbonyliron lactone complexes

SV Ley, G Meek

Chem. Commun.

(1996)

317

(doi: 10.1039/CC9960000317)

Diastereoselective addition reactions of allylstannanes to carbonyl groups in the side-chain of π-allyltricarbonyliron lactone complexes

SV Ley, LR Cox

Chem. Commun.

(1996)

657

(doi: 10.1039/cc9960000657)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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