Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents
– Journal of the Chemical Society - Perkin Transactions 1
(1998)
3127
(doi: 10.1039/a805997g)
Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents
– Journal of the Chemical Society Perkin Transactions 1
(1998)
3127
(doi: 10.1039/a805997g)
A new route to functionalised π-allyltricarbonyliron lactam complexes from aziridines and their use in stereoselective synthesis and oxidative conversion to β-lactams
– Chemical Communications
(1998)
1995
(doi: 10.1039/a806236f)
Molybdenum(II)- and tungsten(II)-catalyzed allylic substitution
– ABSTR PAP AM CHEM S
(1998)
216,
U548
Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1998)
2243
(doi: 10.1039/a803612h)
Clean three-step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagents
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1998)
2235
(doi: 10.1039/a803609h)
Synthesis of the acyltetronic acid ionophore tetronasin (ICI M139603)
– Journal of the Chemical Society Perkin Transactions 1
(1998)
2259
(doi: 10.1039/a804170i)
Use of polymer supported reagents for clean multi-step organic synthesis: preparation of amines and amine derivatives from alcohols for use in compound library generation
– J CHEM SOC PERK T 1
(1998)
2239
(doi: 10.1039/a803611j)
Stereoelectronic effects in the reactions of conformationally restricted, substituted cyclohexane-1,2-diones with 1,2-diols
– Tetrahedron: Asymmetry
(1998)
9,
2471
Mukaiyama aldol reactions of pi-allyltricarbonyliron lactone and lactam complexes bearing trimethylsilyl enol ether side-chains. Not just formal, but genuine 1,7 induction of chirality
– Chemical Communications
(1998)
1339
(doi: 10.1039/a802878h)
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