Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
A short and efficient stereoselective synthesis of the polyhydroxylated macrolactone (+)-aspicillin.
– Organic Letters
(2000)
2,
123
(doi: 10.1021/ol991214s)
Clean and efficient synthesis of azo dyes using polymer-supported reagents
– Green Chemistry
(2000)
2,
43
(doi: 10.1039/b000816h)
Methyl 2,3-O-(6,6'-octahydro-6,6'-BI-2H-PYRAN-2,2'-DIYL)-α-D-galactopyranoside [ α-D-Galactopyranoside, methyl, 2,3-O-(octahydro[2,2'-bi-2H-pyran]-2,2'-diyl-, [2(2R,2'R)-] ]
– Organic Syntheses
(2000)
77,
212
(doi: 10.15227/orgsyn.077.0212)
Preparation of desymmetrized meso-tartrate derivatives: Synthesis and utility of (R′,R′,R,-S)-2,3-butane diacetal protected dimethyl tartrate
– Chemtracts
(2000)
13,
66
Reductive decomplexation of π-allyltricarbonyliron lactone complexes: a new route to stereodefined acyclic 1,5-diols and 1,5,7-triols
– Journal of the Chemical Society, Perkin Transactions 1
(2000)
211
(doi: 10.1039/a907630a)
New strategies for organic catalysis: The first highly enantioselective organocatalytic Diels-Alder reaction
– Chemtracts
(2000)
13,
592
Parallel solution-phase syntheses of functionalised bicyclo[2.2.2]octanes: Generation of a library using orchestrated multistep sequences of polymer-supported reagents and sequesterants
– Journal of the Chemical Society, Perkin Transactions 1
(2000)
3645
(doi: 10.1039/b003129l)
A short and efficient stereoselective synthesis of the potent 5- lipoxygenase inhibitor CMI-977
– Synthetic Communications
(2000)
30,
1955
(doi: 10.1080/00397910008087245)
Tri-n-butyl[2-(trimethylsilyl)-ethoxymethoxymethyl]stannane: A Convenient Hydroxymethyl Anion Equivalent
– Synlett
(2000)
2000,
455
(doi: 10.1055/s-2000-6559)
Deracemization of Baylis-Hillman adducts
– Chemtracts
(2000)
13,
596
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