Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing α-1,3-fucosyltransferase V
– Bioorganic and Medicinal Chemistry
(2000)
8,
2519
Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil.
– Bioorg Med Chem Lett
(2000)
10,
1983
Combined Application of Analytical Techniques for the Characterization of Polymer Supported Species
– ACS Combinatorial Science
(2000)
2,
491
(doi: 10.1021/cc000021p)
Chemo-enzymatic synthesis of fluorinated sugar nucleotide: Useful mechanistic Probes for glycosyltransferases
– Bioorganic & Medicinal Chemistry
(2000)
8,
1937
Synthesis of high-mannose type neoglycolipids: active targeting of liposomes to macrophages in gene therapy.
– Chemistry - A European Journal
(2000)
6,
1416
Pinene-derived bipyridine ligands (PINDY) in asymmetric catalysis.
– ABSTR PAP AM CHEM S
(2000)
219,
U132
Polymer supported reagents in synthesis: preparation of bicyclo[2.2.2] octane derivates via Tandem Michael addition reactions and subsequent combinatorial decoration.
– J Comb Chem
(2000)
2,
104
(doi: 10.1021/cc9900697)
Rapid assembly of oligosaccharides: 1,2-Diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides
– Tetrahedron: Asymmetry
(2000)
11,
173
A short and efficient stereoselective synthesis of the polyhydroxylated macrolactone (+)-aspicillin.
– Organic letters
(2000)
2,
123
(doi: 10.1021/ol991214s)
Parallel solution-phase syntheses of functionalised bicyclo-[2.2.2]octanes: Generation of a library using orchestrated multi-step sequences of polymer-supported reagents and sequesterants
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2000)
3645
(doi: 10.1039/b003129l)
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