Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Pinene-derived bipyridine ligands (PINDY) in asymmetric catalysis.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2000)
219
U132
Polymer supported reagents in synthesis: preparation of bicyclo[2.2.2] octane derivates via Tandem Michael addition reactions and subsequent combinatorial decoration.
J Comb Chem
(2000)
2
104
(doi: 10.1021/cc9900697)
Rapid assembly of oligosaccharides: 1,2-Diacetal-mediated reactivity tuning in the coupling of glycosyl fluorides
Tetrahedron Asymmetry
(2000)
11
173
A Short and Efficient Stereoselective Synthesis of the Polyhydroxylated Macrolactone (+)-Aspicilin
Organic Letters
(2000)
2
123
(doi: 10.1021/ol991214s)
Tri-n-butyl[2-(trimethylsilyl)-ethoxymethoxymethyl]stannane: A convenient hydroxymethyl anion equivalent
Synlett
(2000)
2000
455
(doi: 10.1055/s-2000-6559)
Methyl 2,3-O-(6,6'-octahydro-6,6'-BI-2H-PYRAN-2,2'-DIYL)-α-D-galactopyranoside [ α-D-Galactopyranoside, methyl, 2,3-O-(octahydro[2,2'-bi-2H-pyran]-2,2'-diyl-, [2(2R,2'R)-] ]
Organic Syntheses
(2000)
77
212
(doi: 10.15227/orgsyn.077.0212)
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CHEMISTRY IN BRITAIN
(2000)
36
3
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CHEMISTRY IN BRITAIN
(2000)
36
23
New strategies for organic catalysis: The first highly enantioselective organocatalytic Diels-Alder reaction
Chemtracts
(2000)
13
592
A Short and Efficient Stereoselective Synthesis of the Potent 5-Lipoxygenase Inhibitor CMI-977
Synthetic Communications
(2000)
30
1955
(doi: 10.1080/00397910008087245)
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