Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-(S,S )-(cis-6-methyltetrahydropyran-2-yl)acetic acid, a component of civet

DJ Dixon, SV Ley, EW Tate

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

2385

(doi: 10.1039/b001243m)

The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahyclropyranyl ether derivatives

DJ Dixon, SV Ley, EW Tate

Journal of the Chemical Society, Perkin Transactions 1

(2000)

1829

(doi: 10.1039/a909302h)

Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: An investigation of the reaction mechanism via a double isotopic labelling crossover study

MF Buffet, DJ Dixon, GL Edwards, SV Ley, EW Tate

Journal of the Chemical Society, Perkin Transactions 1

(2000)

1815

(doi: 10.1039/a909300a)

1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using π-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of α-substituted β-hydroxy carbonyl compounds

SV Ley, EA Wright

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

1677

(doi: 10.1039/b002056g)

A short stereoselective total synthesis of the fusarium toxin equisetin

LT Burke, DJ Dixon, SV Ley, F Rodríguez

Organic Letters

(2000)

3611

(doi: 10.1021/ol006493u)

The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C

DJ Dixon, SV Ley, DJ Reynolds

Angewandte Chemie International Edition

(2000)

3622

(doi: 10.1002/1521-3773(20001016)39:20<3622::AID-ANIE3622>3.0.CO;2-H)

The Total Synthesis of the Annonaceous Acetogenin, Muricatetrocin C We thank the EPSRC (D.J.D. and D.J.R.), the Novartis Research Fellowship (S.V.L.), and the BP Research Endowment (S.V.L.) for generous financial support for this work.

DJ Dixon, SV Ley, DJ Reynolds

Angew Chem Int Ed Engl

(2000)

3622

(doi: 10.1002/1521-3773(20001016)39:20<3622::aid-anie3622>3.0.co;2-h)

Chemoenzymatic synthesis of l-galactosylated dimeric Sialyl Lewis X structures employing α-1,3-fucosyltransferase V

A Düffels, LG Green, R Lenz, SV Ley, SP Vincent, CH Wong

Bioorganic & medicinal chemistry

(2000)

2519

(doi: 10.1016/S0968-0896(00)00187-5)

Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil.

IR Baxendale, SV Ley

Bioorganic & medicinal chemistry letters

(2000)

1983

(doi: 10.1016/s0960-894x(00)00383-8)

Combined application of analytical techniques for the characterization of polymer supported species

P Grice, AG Leach, SV Ley, A Massi, DM Mynett

Journal of Combinatorial Chemistry

(2000)

491

(doi: 10.1021/cc000021p)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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