Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

1,2-Diacetals: A New Opportunity for Organic Synthesis

SV Ley, DK Baeschlin, DJ Dixon, AC Foster, SJ Ince, HW Priepke, DJ Reynolds

Chemical Reviews

(2000)

101

(doi: 10.1021/cr990101j)

A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis

C Jamieson*, MS Congreve, DF Emiabata-Smith, SV Ley

Synlett

(2000)

2000

1603

(doi: 10.1055/s-2000-7917)

Methyl 2,3-O-(6,6′-octahydro-6,6′-bi-2h-pyran-2,2′-diyl)-α-d- galactopyranoside: α-D-Galactopyranoside, methyl, 2,3-O-octahydro[2,2′-bi-2H-pyran]-2,2′-diyl-, [2(2R,2′R)-]

SV Ley, HMI Osborn

Organic Syntheses

(2000)

212

1,7-Asymmetric induction of chirality in a Mukaiyama aldol reaction using pi-allyltricarbonyliron lactone complexes: highly diastereoselective synthesis of alpha-substituted beta-hydroxy carbonyl compounds

SV Ley, EA Wright

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

1677

(doi: 10.1039/b002056g)

The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahyclropyranyl ether derivatives

DJ Dixon, SV Ley, EW Tate

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

1829

(doi: 10.1039/a909302h)

The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol

SV Ley, S Burckhardt

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2000)

3028

(doi: 10.1039/b005942k)

Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: An investigation of the reaction mechanism via a double isotopic labelling crossover study

MF Buffet, DJ Dixon, GL Edwards, SV Ley, EW Tate

J CHEM SOC PERK T 1

(2000)

1815

(doi: 10.1039/a909300a)

Multi-step organic synthesis using solid-supported reagents and scavengers: A new paradigm in chemical library generation

SV Ley, IR Baxendale, RN Bream, PS Jackson, AG Leach, DA Longbottom, M Nesi, JS Scott, RI Storer, SJ Taylor

Journal of the Chemical Society Perkin Transactions 1

(2000)

3815

(doi: 10.1039/b006588i)

Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-( S , S )-( cis -6-methyltetrahydropyran-2-yl)acetic acid, a component of civet

DJ Dixon, SV Ley, EW Tate

Journal of the Chemical Society Perkin Transactions 1

(2000)

2385

(doi: 10.1039/b001243m)

A Short Stereoselective Total Synthesis of the Fusarium Toxin Equisetin

LT Burke, DJ Dixon, SV Ley, F Rodríguez

Org Lett

(2000)

3611

(doi: 10.1021/ol006493u)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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