Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Analytical construct resins for analysis of solid-phase chemistry.
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8,
The total synthesis of the annonaceous acetogenin, muricatetrocin C.
– Chemistry (Weinheim an der Bergstrasse, Germany)
(2002)
8,
Solid-supported reagents for multi-step organic synthesis: preparation and application.
– ChemMedChem
(2002)
57,
321
Analytical Construct Resins for Analysis of Solid-Phase Chemistry
– Chemistry - A European Journal
(2002)
8,
1768
The total synthesis of the annonaceous acetogenin, muricatetrocin C
– Chemistry - A European Journal
(2002)
8,
1621
The simultaneous use of immobilised reagents for the one-pot conversion of alcohols to carboxylic acids
– Journal of the Chemical Society. Perkin Transactions 1
(2002)
2,
1024
(doi: 10.1039/b201776h)
The use of π-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides α- and β-zearalenol
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2002)
2,
874
(doi: 10.1039/b201164f)
Total synthesis of the cyclic heptapeptide Argyrin B: A new potent inhibitor of T-cell independent antibody formation
– Org Lett
(2002)
4,
711
(doi: 10.1021/ol017184m)
The effects of phytochemical pesticides on the growth of cultured invertebrate and vertebrate cells
– Pest Manag Sci
(2002)
58,
268
(doi: 10.1002/ps.449)
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride-calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative
– J CHEM SOC PERK T 1
(2002)
2,
2237
(doi: 10.1039/b207068p)
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