Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Butane-2,3-Diacetal-Desymmetrized Glycolic Acid—A New Building Block for the Stereoselective Synthesis of Enantiopureα-Hydroxy Acids
Angewandte Chemie (International ed. in English)
(2001)
40
2906
Development and application of a carbonyl-13C-enriched backbone amide linker for solid-phase reaction monitoring
ACS Combinatorial Science
(2001)
3
397
(doi: 10.1021/cc010012w)
Solid-phase development of a L-hydroxybenzotriazole linker for heterocycle synthesis using analytical constructs.
J Comb Chem
(2001)
3
387
(doi: 10.1021/cc0100114)
New catalysts for olefin metathesis
Chemtracts
(2001)
14
88
Studies toward the total synthesis of rapamycin.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2001)
221
U185
Approaches to the total synthesis of antascomicin A.
ABSTR PAP AM CHEM S
(2001)
221
U198
A New Phase-Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal-Chelated Tagging
Angewandte Chemie International Edition
(2001)
40
1053
A New Phase‐Switch Method for Application in Organic Synthesis Programs Employing Immobilization through Metal‐Chelated Tagging
Angewandte Chemie International Edition
(2001)
40
1053
A polymer-supported thionating reagent
Journal of the Chemical Society Perkin Transactions 1
(2001)
358
(doi: 10.1039/b008814p)
Synthesis of new chiral 2,2′-bipyridyl-type ligands, their coordination to molybdenum(0), copper(II), and palladium(II), and application in asymmetric allylic substitution, allylic oxidation, and cyclopropanation
Organometallics
(2001)
20
673
(doi: 10.1021/om000850n)
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