Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
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CHEMISTRY IN BRITAIN
(2002)
38
20
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride-calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative
Journal of the Chemical Society Perkin Transactions 1
(2002)
2
2237
(doi: 10.1039/b207068p)
Consecutive three- and four-component coupling reactions with anions generated from a butane diacetal desymmetrized glycolic acid derivative
Angewandte Chemie International Edition
(2001)
40
4763
Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers
Journal of the Chemical Society Perkin Transactions 1
(2001)
2
143
(doi: 10.1039/b109482n)
Highly Diastereoselective Michael Addition Reactions of Butane-2,3-diacetal Desymmetrized Glycolic Acid. Preparation of α-Hydroxy-γ-amino Acid Derivatives
Organic Letters
(2001)
3
3753
(doi: 10.1021/ol016708f)
Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters
Organic letters
(2001)
3
3749
(doi: 10.1021/ol016707n)
Tetra-N-propylammonium perruthenate: a case study in catalyst recovery and re-use involving tetraalkylammonium salts
Chemical Communications
(2001)
1
2278
(doi: 10.1039/b107966m)
Rapid assembly of anti , anti -1,2,3-triol motifs via stereoselective addition of organometallics to aldehydes obtained from ( R ′, R ′, S , R )-2,3-butane diacetal protected butanetetraol derivatives
Journal of the Chemical Society, Perkin Transactions 1
(2001)
1
2516
(doi: 10.1039/b105118k)
The Bestmann ylide as a multi-purpose wittig reagent
Chemtracts
(2001)
14
386
Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito.
Molecular and biochemical parasitology
(2001)
116
17
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