Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total synthesis of the cyclic heptapeptide Argyrin B: A new potent inhibitor of T-cell independent antibody formation
Org Lett
(2002)
4
711
(doi: 10.1021/ol017184m)
The effects of phytochemical pesticides on the growth of cultured invertebrate and vertebrate cells
Pest management science
(2002)
58
268
(doi: 10.1002/ps.449)
A mild, enantioselective synthesis of (R)-salmeterol via sodium borohydride–calcium chloride asymmetric reduction of a phenacyl phenylglycinol derivative
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(2002)
2
2237
(doi: 10.1039/b207068p)
A polymer-supported iridium catalyst for the stereoselective isomerisation of double bonds
Synlett
(2002)
2002
0516
(doi: 10.1055/s-2002-20483)
A clean conversion of aldehydes to nitriles using a solid-supported hydrazine
Synlett
(2002)
2002
0775
(doi: 10.1055/s-2002-25333)
Application of polymer-supported enzymes and reagents in the synthesis of γ-aminobutyric acid (GABA) analogues
Synlett
(2002)
1641
(doi: 10.1055/s-2002-34249)
Palladium Acetate in Polyurea Microcapsules: A Recoverable and Reusable Catalyst for Hydrogenations
Synlett
(2002)
2002
1843
(doi: 10.1055/s-2002-34862)
Reductive decomplexation of π-allyltricarbonyliron lactone complexes;: a new route to stereo-defined 1,7-diols and 2,3-diene-1,7-diols
Chemical communications (Cambridge, England)
(2002)
2
2130
(doi: 10.1039/b206406p)
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CHEMISTRY IN BRITAIN
(2002)
38
20
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