Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Formation of monohomocyclooctatetraene dianions in liquid ammonia. Analysis of the nucleophilic reactivity of the cyclononatrienyl anions generated upon solvent protonation

LA Paquette, SV Ley, SG Traynor, JT Martin, JM Geckle

Journal of the American Chemical Society

(2002)

98

8162

(doi: 10.1021/ja00441a046)

Polyurea-encapsulated palladium(ii) acetate: a robust and recyclable catalyst for use in conventional and supercritical mediaElectronic supplementary information (ESI) available: representative experimental procedures. See http://www.rsc.org/suppdata/cc/b2/b200677b/

SV Ley, C Ramarao, RS Gordon, AB Holmes, AJ Morrison, IF McConvey, IM Shirley, SC Smith, MD Smith

Chemical Communications

(2002)

2

1134

(doi: 10.1039/b200677b)

Encapsulation of palladium in polyurea microcapsules

C Ramarao, SV Ley, SC Smith, IM Shirley, N DeAlmeida

Chemical communications (Cambridge, England)

(2002)

10

1132

(doi: 10.1039/b200674j)

Analytical construct resins for analysis of solid-phase chemistry.

MS Congreve, SV Ley, JJ Scicinski

Chemistry (Weinheim an der Bergstrasse, Germany)

(2002)

8

The total synthesis of the annonaceous acetogenin, muricatetrocin C.

DJ Dixon, SV Ley, DJ Reynolds

Chemistry (Weinheim an der Bergstrasse, Germany)

(2002)

8

Solid-supported reagents for multi-step organic synthesis: preparation and application

SV Ley, IR Baxendale, G Brusotti, M Caldarelli, A Massi, M Nesi

Farmaco (Societa chimica italiana : 1989)

(2002)

57

321

(doi: 10.1016/S0014-827X(02)01210-7)

Analytical Construct Resins for Analysis of Solid‐Phase Chemistry

MS Congreve, SV Ley, JJ Scicinski

Chemistry

(2002)

8

1768

(doi: 10.1002/1521-3765(20020415)8:8<1768::AID-CHEM1768>3.0.CO;2-J)

The total synthesis of the annonaceous acetogenin, muricatetrocin C.

DJ Dixon, SV Ley, DJ Reynolds

Chemistry (Weinheim an der Bergstrasse, Germany)

(2002)

8

1621

(doi: 10.1002/1521-3765(20020402)8:7<1621::AID-CHEM1621>3.0.CO;2-8)

The simultaneous use of immobilised reagents for the one-pot conversion of alcohols to carboxylic acids

K Yasuda, SV Ley

J CHEM SOC PERK T 1

(2002)

2

1024

(doi: 10.1039/b201776h)

The use of pi-allyltricarbonyliron lactone complexes in the synthesis of the resorcylic macrolides alpha- and beta-zearalenol

S Burckhardt, SV Ley

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(2002)

2

874

(doi: 10.1039/b201164f)