Yusuf Hamied Department of Chemistry

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis. 

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Immobilization of Thallium by Tandem Oxidation/Reduction-Complexation of Thallium(I/III)
IA Kahwa, D Miller, M Mitchel, FR Fronczek, RG Goodrich, DJ Williams, CA O'Mahoney, AMZ Slawin, SV Ley, CJ Groombridge
Inorganic Chemistry
(2002)
31
(doi: 10.1021/ic00045a020)
Unsaturated heterocyclic systems. XCII. Nitrogen analogs of 1,6-methano[12]annulene. Effect on valence tautomerism of the locus of aza substitution
LA Paquette, HC Berk, SV Ley
The Journal of Organic Chemistry
(2002)
40
(doi: 10.1021/jo00895a020)
Total Synthesis of the Ionophore Antibiotic X-14547A (Indanomycin)
MP Edwards, SV Ley, SG Lister, BD Palmer, DJ Williams
Journal of Organic Chemistry
(2002)
49
(doi: 10.1021/jo00193a014)
Synthesis of trifluoromethyl ketones using polymer-supported reagents
IR Baxendale, SV Ley, W Lumeras, M Nesi
Comb Chem High Throughput Screen
(2002)
5
(doi: 10.2174/1386207024607220)
Tetracyanoethylene Addition to Iron Tricarbonyl Complexes of Substituted Cyclooctatetraenes. Regioselectivity Considerations during Formation of the 2,3,4,10-Tetrahapto Adducts
LA Paquette, SV Ley, S Maiorana, DF Schneider, MJ Broadhurst, RA Boggs
Journal of the American Chemical Society
(2002)
97
(doi: 10.1021/ja00849a031)
Alkali metal reduction studies of cis- and trans-bicyclo[6.1.0]nona-2,4,6-trienes in liquid ammonia. Evidence for the high basicity of monohomocyclooctatetraene dianions
SV Ley, LA Paquette
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00828a021)
A FACILE ROUTE TO IMIDAZOL-4-YL ANIONS AND THEIR REACTION WITH CARBONYL-COMPOUNDS
RM Turner, SD Lindell, SV Ley
The Journal of Organic Chemistry
(2002)
56
(doi: 10.1021/jo00020a002)
An Efficient Synthesis of (-)-Triquinacene-2-carboxylic Acid
LA Paquette, SV Ley, WB Farnham
Journal of the American Chemical Society
(2002)
96
(doi: 10.1021/ja00808a081)
Thermal Isomerization of Homoazocines
GD Ewing, SV Ley, LA Paquette
Journal of the American Chemical Society
(2002)
100
(doi: 10.1021/ja00477a066)
QUESTION OF DELOCALIZATION IN ANCHORED IONS WITH POTENTIAL TRIS-HOMO-AROMATIC CHARACTER .1. REDUCTION OF TRICYCLO[5.4.1.O4,12]DODECA-2,5,8,10-TETRAENE AS A ROUTE TO 10PI11C DIANION
LA Paquette, MJ Kukla, SV Ley, SG Traynor
Journal of the American Chemical Society
(2002)
99
(doi: 10.1021/ja00456a037)

Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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