Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total synthesis of polycephalin C and determination of the absolute configurations at the 3′′,4′′ ring junction
Angewandte Chemie International Edition
(2002)
41
2786
New tools and concepts for modern organic synthesis
Nature Reviews Drug Discovery
(2002)
1
573
(doi: 10.1038/nrd871)
A polymer-supported [1,3,2]oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an Ugi reaction
Bioorganic and Medicinal Chemistry Letters
(2002)
12
1813
A concise synthesis of carpanone using solid-supported reagents and scavengers
Journal of the Chemical Society, Perkin Transactions 1
(2002)
2
1850
(doi: 10.1039/b203388g)
Synthesis of taurospongin A: a potent inhibitor of DNA polymerase and HIV reverse transcriptase, using π-allyltricarbonyliron lactone complexes
Chemical Communications
(2002)
2
1624
(doi: 10.1039/b204994p)
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions
Angewandte Chemie International Edition
(2002)
41
2194
Directed Syntheses of the Isomeric Dimethylcyclooctatetraenes and a Study of Their Polarographic and Alkali Metal Reduction
Journal of the American Chemical Society
(2002)
96
5806
(doi: 10.1021/ja00825a019)
Homotropylium-8-Sulfinate Complexes by SbF5-Promoted Ring Opening of 9-Thiabicyclo[4.2.1]nona-2,4,7-Triene and 9-Thiabarbaralane 9,9-Dioxides
Journal of the American Chemical Society
(2002)
98
152
(doi: 10.1021/ja00417a023)
Luminescence dynamics and carbon-13 NMR characteristics of dinuclear complexes exhibiting coupled lanthanide(III) cation pairs
The Journal of Physical Chemistry
(2002)
96
7021
(doi: 10.1021/j100196a033)
Synthesis and Reducibility of Homo-2-methoxyazocines and Their Benzo-Fused Derivatives. An Examination of Heteroatomic Influences on the Possible Generation of 9C-10π Homoaromatic Dianions
Journal of Organic Chemistry
(2002)
43
4712
(doi: 10.1021/jo00419a007)
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