Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Total synthesis of the cyclic peptide Argyrin B
European Journal of Organic Chemistry
(2002)
2002
3995
Application of ReactArray robotics and design of experiments techniques in optimisation of supported reagent chemistry
Organic Process Research & Development
(2002)
6
823
(doi: 10.1021/op010108e)
Butane-2,3-diacetals of glyceraldehyde: a stable alternative to glyceraldehyde acetonide.
Angew Chem Int Ed Engl
(2002)
41
3898
Synthesis of the beta(2) agonist (R)-salmeterol using a sequence of supported reagents and scavenging agents
Org Lett
(2002)
4
3793
(doi: 10.1021/ol020128g)
Highly selective entry to the azadirachtin skeleton via a Claisen rearrangement/radical cyclization sequence.
Organic Letters
(2002)
4
3847
(doi: 10.1021/ol0201557)
Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid
Synthesis
(2002)
2002
1973
(doi: 10.1055/s-2002-34377)
Synthesis, structure revision, and absolute configuration of (+)-didemniserinolipid B, a serinol marine natural product from a tunicate Didemnum sp.
Organic letters
(2002)
4
3223
(doi: 10.1021/ol026421y)
Application of analytical constructs to the development of an indole safety-catch linker family for solid phase organic synthesis.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2002)
224
U175
Total synthesis of Argyrin B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2002)
224
U242
Synthetic studies toward the total synthesis of Azadirachtin.
ABSTR PAP AM CHEM S
(2002)
224
U242
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