Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Development of an organic-catalyst mediated cyclopropanation reaction
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U361
Studies toward the total synthesis of 10-hydroxyasimicin.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U349
Development of β-keto 1,3-dithianes:: Versatile platforms for organic synthesis.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2003)
225,
U342
Organic-catalyst-mediated cyclopropanation reaction.
– Angewandte Chemie (International ed. in English)
(2003)
42,
828
(doi: 10.1002/anie.200390222)
Transfer hydrogenation using recyclable polyurea-encapsulated palladium: Efficient and chemoselective reduction of aryl ketones
– Chemical communications (Cambridge, England)
(2003)
3,
678
(doi: 10.1039/b300074p)
A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids
– Chemical Communications
(2003)
468
(doi: 10.1039/b210673f)
Reductive decomplexation of pi-allyltricarbonyliron lactone complexes using sodium naphthalenide as a route to stereodefined 1,7-diols and 2,3-diene-1,7-diols
– Org Biomol Chem
(2003)
1,
3197
(doi: 10.1039/b306861g)
Synthesis of Enantiomers ofButane-1,2-diacetal-Protected Glyceraldehyde and of (R,R)-Butane-1,2-diacetal-ProtectedGlycolic Acid
– Synthesis
(2003)
1598
(doi: 10.1055/s-2003-40519)
Copper(I)-catalyzed preparation of (E)-3-iodoprop-2-enoic acid: [(2-propenoic acid, 3-iodo-, (2E)-)]
– Organic Syntheses
(2003)
80,
129
(doi: 10.15227/orgsyn.080.0129)
A rapid stereocontrolled synthesis of the 3 a -hydroxy-pyrrolo[2,3- b ]indole skeleton, a building block for 10 b -hydroxy-pyrazino[1′,2′:1,5]pyrrolo[2,3- b ]indole-1,4-diones
– Organic & biomolecular chemistry
(2003)
1,
3492
(doi: 10.1039/b308288a)
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