Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of (-)-Gloeosporone, a fungal autoinhibitor of spore germination using a pi-allyltricarbonyliron lactone complex as a templating architecture for 1,7-diol construction
Organic & Biomolecular Chemistry
(2003)
1
3263
(doi: 10.1039/b308793j)
Total synthesis of the phytotoxic agent herbarumin II using butane diacetals of glycolic acid as building blocks
Synlett
(2003)
1186
(doi: 10.1055/s-2003-39892)
Rhodium-catalyzed coupling of heterocycles and alkenes: A novel mechanism of C-H activation
Chemtracts
(2003)
16
443
Development of new synthetic tools for the preparation of biologically active molecules
CHEMICAL PROBES IN BIOLOGY: SCIENCE AT THE INTERFACE OF CHEMISTRY, BIOLOGY AND MEDICINE
(2003)
129
235
Microencapsulation of Osmium Tetroxide in Polyurea
Organic Letters
(2002)
5
185
(doi: 10.1021/ol020225+)
Benzotriazoles in solid-phase organic chemistry
Chemtracts
(2002)
15
751
Analytical Techniques for Small Molecule Solid Phase Synthesis
Current medicinal chemistry
(2002)
9
2103
(doi: 10.2174/0929867023368737)
Total synthesis of the cyclic peptide Argyrin B
European Journal of Organic Chemistry
(2002)
2002
3995
Application of ReactArray Robotics and Design of Experiments Techniques in Optimisation of Supported Reagent Chemistry
Organic Process Research & Development
(2002)
6
823
(doi: 10.1021/op010108e)
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