Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles.
– Journal of combinatorial chemistry
(2004)
6,
332
(doi: 10.1021/cc049977g)
Development of an Indole Safety-Catch Linker Using Analytical Constructs
– ACS Combinatorial Science
(2004)
6,
375
(doi: 10.1021/cc0499791)
Anomeric oxygen to carbon rearrangements of alkynyl tributylstannane derivatives of furanyl (gamma)- and pyranyl (delta)-lactols.
– Organic & Biomolecular Chemistry
(2004)
2,
1145
(doi: 10.1039/b316858a)
Catalytic polymer-supported potassium thiophenolate in methanol as a method for the removal of ester, amide, and thioacetate protecting groups
– Synlett
(2004)
675
(doi: 10.1055/s-2004-817786)
Modern synthetic methods for copper-mediated C(aryl)-O, C(aryl)N, and C(aryl)-S bond formation (vol 42, pg 5400, 2003)
– Angewandte Chemie International Edition
(2004)
43,
1043
(doi: 10.1002/anie.200490023)
5-pyrrolidin-2-yltetrazole: A new, catalytic, more soluble alternative to proline in an organocatalytic asymmetric Mannich-type reaction
– Synlett
(2004)
2004,
558
(doi: 10.1055/s-2004-817745)
Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors.
– Organic & Biomolecular Chemistry
(2004)
2,
611
(doi: 10.1039/b313414h)
Preface - In honor of Professor Leo A. Paquette and on the occasion of his 70th birthday
– HETEROCYCLES
(2004)
62,
1
The synthesis of (-)-gloeosporone, a potent fungal autoinhibitor of spore germination using a pi-allyltricarbonyl-iron lactone complex and a new reductive decomplexation procedure for the installation of the embedded 1,7-diol component of the natural product
– Heterocycles
(2004)
62,
619
(doi: 10.3987/com-03-s(p)55)
A Facile One‐Pot Synthesis of a Trisaccharide Unit from the Common Polysaccharide Antigen of Group B Streptococci Using Cyclohexane‐1, 2‐diacetal (CDA) Protected Rhamnosides
– Angewandte Chemie International Edition
(2003)
33,
2292
(doi: 10.1002/anie.199422921)
- <
- 51 of 105