Professor Steve Ley CBE FRS FMedSci | Page 6 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Rapid, selective and stable HaloTag-Lb ADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides

J Döbber, M Pohl, SV Ley, B Musio

– Reaction Chemistry and Engineering

(2018)

3,

8

(doi: 10.1039/c7re00173h)

Real-time spectroscopic analysis enabling quantitative and safe consumption of fluoroform during nucleophilic trifluoromethylation in flow.

B Musio, E Gala, SV Ley

– ACS Sustainable Chemistry & Engineering

(2018)

6,

1489

(doi: 10.1021/acssuschemeng.7b04012)

Immobilized Reagents and Multistep Processes

SV Ley, DL Browne, M O'Brien

(2018)

2018,

273

(doi: 10.1055/sos-SD-228-00177)

Engineering Chemistry to Enable Bioactive Small Molecule Discovery

SV Ley, D Fitzpatrick, C Battilocchio

(2018)

10,

184

(link to publication)

C-H Functionalisation of Aldehydes using Light Generated, Non-Stabilised Diazo Compounds in Flow

P Dingwall, A Greb, LNS Crespin, R Labes, B Musio, J-S Poh, P Pasau, DC Blakemore, SV Ley

– Chemical Communications

(2018)

54,

11685

(doi: 10.1039/c8cc06202a)

Organic Photocatalysis for the Radical Couplings of Boronic Acid Derivatives in Batch and Flow

F Lima, L Grunenberg, HBA Rahman, R Labes, J Sedelmeier, SV Ley

– Chemical communications (Cambridge, England)

(2018)

54,

5606

(doi: 10.1039/c8cc02169d)

Preparation of homoallylic amines via a three-component coupling process

X Ou, R Labes, C Battilocchio, S Ley

– Organic & biomolecular chemistry

(2018)

16,

6652

(doi: 10.1039/C8OB01831F)

9 Immobilized Reagents and Multistep Processes

SV Ley, DL Browne, M O’Brien

(2018)

2018,

273

(doi: 10.1055/sos-sd-228-00177)

Award Address (Arthur C. Cope Award sponsored by the Arthur C. Cope Fund). Natural product synthesis as an inspiration for discovery

S Ley

– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY

(2018)

256,

(link to publication)

A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross‐Coupling Reactions

A Greb, J Poh, S Greed, C Battilocchio, P Pasau, DC Blakemore, SV Ley

– Angewandte Chemie

(2017)

129,

16829

(doi: 10.1002/ange.201710445)