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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Rapid, selective and stable HaloTag-LbADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides
J Döbber, M Pohl, SV Ley, B Musio
– Reaction Chemistry & Engineering
(2018)
3,
8
Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow
F Lima, L Grunenberg, HBA Rahman, R Labes, J Sedelmeier, SV Ley
– Chemical communications (Cambridge, England)
(2018)
54,
5606
Immobilized reagents and multistep processes
SV Ley, DL Browne, M O’Brien
(2018)
2018,
273
C-H Functionalisation of Aldehydes using Light Generated, Non-Stabilised Diazo Compounds in Flow
P Dingwall, A Greb, LNS Crespin, R Labes, B Musio, J-S Poh, P Pasau, DC Blakemore, SV Ley
– Chem Commun (Camb)
(2018)
54,
11685
Award Address (Arthur C. Cope Award sponsored by the Arthur C. Cope Fund). Natural product synthesis as an inspiration for discovery
S Ley
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256,
Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow
B Musio, E Gala, SV Ley
– ACS Sustainable Chemistry and Engineering
(2018)
6,
1489
Engineering Chemistry to Enable Bioactive Small Molecule Discovery
SV Ley, D Fitzpatrick, C Battilocchio
(2018)
10,
184
Preparation of homoallylic amines via a three-component coupling process
X Ou, R Labes, C Battilocchio, S Ley
– Organic & Biomolecular Chemistry
(2018)
16,
6652
Immobilized Reagents and Multistep Processes
SV Ley, DL Browne, M O'Brien
(2018)
2018,
273
A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl–Alkyl Cross‐Coupling Reactions
A Greb, J Poh, S Greed, C Battilocchio, P Pasau, DC Blakemore, SV Ley
– Angewandte Chemie
(2017)
129,
16829
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk