Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Enantioselective Organocatalytic Cyclopropanation via Ammonium Ylides
– Angewandte Chemie International Edition
(2004)
43,
4641
(doi: 10.1002/anie.200460234)
The preparation and alkylation of a butanedione-derived chiral glycine equivalent and its use for the synthesis of alpha-amino acids and alpha,alpha-disubstituted amino acids
– Tetrahedron
(2004)
60,
7679
(doi: 10.1016/j.tet.2004.06.063)
Synthesis of the C-1/C-15 spiroketal fragment (AB) of spongistatin 1.
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2004)
228,
U77
A concise total synthesis of (+)-okaramine C.
– Organic & biomolecular chemistry
(2004)
2,
2415
(doi: 10.1039/b410180d)
5-Pyrrolidin-2-yltetrazole as an asymmetric organocatalyst for the addition of ketones to nitro-olefins.
– Chem Commun (Camb)
(2004)
10,
1808
(doi: 10.1039/b409646k)
Synthesis of the thapsigargins
– Proceedings of the National Academy of Sciences of the United States of America
(2004)
101,
12073
(doi: 10.1073/pnas.0403300101)
Multi‐Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C
– Chemistry – A European Journal
(2004)
10,
2529
(doi: 10.1002/chem.200305669)
An intramolecular organocatalytic cyclopropanation reaction
– Angew Chem Int Ed Engl
(2004)
43,
2681
(doi: 10.1002/anie.200454007)
Evolving cascades: The Claisen rearrangement in the development of tandem sequences of three or more reactions
– Chemtracts
(2004)
17,
235
Grignard additions to 2-uloses: synthesis of stereochemically pure tertiary alcohols
– Tetrahedron Letters
(2004)
45,
3077
(doi: 10.1016/j.tetlet.2004.02.106)
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